Hycult Biotech/C5a/C5a des Arg, Human, mAb 2952/HM2079/100 µg

来自 : 发布时间：2024-12-23

Description: C5a/C5a des Arg, Human, mAb 2952

Monoclonal antibody 2952 reacts with a neo-epitope on C5a (des-Arg) that is formed upon cleavage of C5 into C5a and C5b. C5 is involved in the activation of the lythic pathway within the complement system which is an important factor in innate immunity. The complement pathways can be divided in the activation pathways and lytic pathway. The activation pathways lead via C3 to the cleavage of the fifth complement component C5. C5a induces smooth muscle contraction, increases vascular permeability, causes degranulation of mast cells and basophils, and release of lysosomal enzymes. In addition C5a stimulates the directed migration of neutrophils, eosinophils, basophils and monocytes. Recent studies indicate the modulation of the acute-phase response in liver and an overall immune response by inducing synthesis of cytokines such as TNF-alpha IL-1beta, IL-6 and IL-8.

Specifications:

Catalog number Product type Quantity Formulation Application Use Isotype Species References Storage and stability Precautions Disease

HM2079

Monoclonal antibodies

100 µg

1 ml (100 µg/ml) 0.2 µm filtered antibody solution in PBS, containing 0.1% bovine serum albumin.

Frozen sections, Functional studies, Immuno assays, Western blot

For immunohistology, and Western blotting, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. For functional studies, in vitro dilutions have to be optimized in users experimental setting.

Mouse IgG1

Human

Nozaki, M et al; Drusen complement components C3a and C5a promote choroidal neovascularisation. PNAS 2006, 103: 2328

Product should be stored at 4°C. Under recommended storage conditions, product is stable for one year

For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result from the use or derivation of this product.

Infectious diseases, Nephrology