4000-520-616
欢迎来到免疫在线!(蚂蚁淘生物旗下平台)  请登录 |  免费注册 |  询价篮
主营:主营:病理学诊断相关的抗体,蛋白质
咨询热线电话
4000-520-616
当前位置: 首页 > 产品中心 > peptide > Hycult Biotech/MASP-2/MAp19, Human, mAb 6G12 | Hycult Biotech/HM2191-500UG
商品详细Hycult Biotech/MASP-2/MAp19, Human, mAb 6G12 | Hycult Biotech/HM2191-500UG
Hycult Biotech/MASP-2/MAp19, Human, mAb 6G12  | Hycult Biotech/HM2191-500UG
Hycult Biotech/MASP-2/MAp19, Human, mAb 6G12 | Hycult Biotech/HM2191-500UG
商品编号: HM2191-500UG
品牌: hycultbiotech
市场价: ¥26820.00
美元价: 16092.00
产地: 美国(厂家直采)
公司:
产品分类: 多肽合成
公司分类: peptide
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
The monoclonal antibody 6G12 reacts with human MASP-2 and human MAp19. MASP-2 is a trypsin-like serine protease and plays an important role in the initiation of the MBL complement activation pathway. Three pathways of complement activation have been reported: the antibody-dependent classical pathway, the antibody-independent alternative pathway and the lectin pathway. Activation of each pathway involves formation of serine protease complexes, which results in activation of the central complement component C3. In the lectin pathway, mannose binding-lectin (MBL)-associated serine proteases (MASPs) form complexes with polymeric lectin molecules which are involved in pattern recognition. Upon binding of the recognition molecules to carbohydrates on the surface of micro organisms, MASPs are converted to their active forms and initiate complement activation. Three types of human MASP have been reported. MASP-1, MASP-2 and MASP-3. Mannan-binding lectin (MBL) and ficolins, in complex with MBL-associated serin proteases (MASPs), are capable of activation the complement system, thus mediating the destruction of infectious agents. MASP-2 cleaves C4 and C2 and is crucial for the activation of downstream complement components. MAp19 is an alternative splicing product of the MASP-2 gene. MAp19 comprises the first two domains of MASP-2 followed by an extra sequence of four unique amino acids (EQSL) at its C-terminal. MASP-2 and MAp19 have been reported to bind to MBL in a calcium-dependent manner.The monoclonal antibody 6G12 reacts with high affinity to the N-terminal end of MASP-2 and Map19.
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登,从1994开始制造检测抗体和蛋白质,主要侧重与病理学诊断有关的全套产品研发,既有纯化的重组蛋白和多肽,也有单抗和多抗,是世界一流的先天免疫领域的研究试剂制造商。