Hycult Biotech/S100A7, Human, ELISA kit | Hycult Biotech/HK378-01
商品编号:
HK378-01
品牌:
hycultbiotech
市场价:
¥11600.00
美元价:
6960.00
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
S100A7 (psoriasin) is a 11.4kDa member of the S100 gene family, which are EF-hand Ca 2+-binding proteins. They are involved in a broad range of intra- and extracellular processes like regulation of calcium homeostasis, cell proliferation, differentiation, apoptosis, immune responses, antimicrobial activity, chemotaxis and inflammation. S100 proteins have a fundamental structural unit which is a highly integrated dimer, some as homodimer and others as heterodimer. S100A7 functions as a homodimer and binds two Zn2+ ions. These ions stabilize the dimer and mediate the function of S100A7 during infection. Extracellular S100A7 functions as a DAMP during infection. S100A7 limits bacterial infection through metal limitation. Furthermore, S100A7interacts with RAGE which drives an NF-B mediated proinflammatory response and recruitment of neutrophils.S100A7 was first discovered as a protein abundantly expressed in psoriatic keratinocytes. Psoriasis is considered a disease of dysregulated epidermal hyper proliferation and inflammation, initiated by multiple mechanisms of the immune system. Possibly, S100A7 adheres directly to and reduces survival of pathogens found on the epidermis and acts as a physical barrier. Originally S100A7 was called a biomarker for psoriasis, but is also find in other skin diseases like atopic dermatitis. Therefore, the protein seems to be a major player in the local innate defense of the skin. Furthermore, S100A7 seems to be involved with breast cancer and squamous cell carcinoma. In vitro it was found to confer a more aggressive behavior.It is strongly recommended to wear gloves. Please be aware the assay is sensitive for any skin or hair flakes: this can give false positive results.
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登,从1994开始制造检测抗体和蛋白质,主要侧重与病理学诊断有关的全套产品研发,既有纯化的重组蛋白和多肽,也有单抗和多抗,是世界一流的先天免疫领域的研究试剂制造商。
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