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当前位置: 首页 > 产品中心 > Sandwich_method_ELISA > Hycult生物技术/α-1-抗胰蛋白酶;A1AT,人类ELISA |杂交生物技术公司/HK387-01
商品详细Hycult生物技术/α-1-抗胰蛋白酶;A1AT,人类ELISA |杂交生物技术公司/HK387-01
Hycult生物技术/α-1-抗胰蛋白酶;A1AT,人类ELISA |杂交生物技术公司/HK387-01
Hycult生物技术/α-1-抗胰蛋白酶;A1AT,人类ELISA |杂交生物技术公司/HK387-01
商品编号: HK387-01
品牌: hycultbiotech
市场价: ¥13720.00
美元价: 8232.00
产地: 美国(厂家直采)
公司:
产品分类: 夹心法ELISA
公司分类: Sandwich_method_ELISA
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
The human alpha-1 antitripsin ELISA detects both the healthy monomeric form (M variant) and the disease associated polymeric forms (Z variants) of human alpha-1-antitrypsin with equal affinity. Alpha-1-antitrypsin is a member of the serine protease inhibitor (serpin) superfamily which are proteins known for their ability to inhibit proteases. It is the most abundant circulating protease inhibitor known. It mainly targets enzymes released by neutrophils, especially neutrophil elastase (NE) but also proteinase 3 (PR3) and Cathepsin G (CG). Serpinopathies are conformational diseases characterized by the polymerization and intracellular retention of members of the serpin superfamily. The best known is Alpha-1-antitrypsin deficiency, with the most common severe deficiency allele being the Z mutation (Glu342Lys). This severe autosomal dominant disorder causes the protein to undergo a conformational transition and form ordered polymers that are retained within hepatocytes. Due to this accumulation of polymers in hepatocytes, blood alpha-1 trypsin levels will decrease leading to chronic uninhibited tissue breakdown. This causes the degradation especially of lung tissue which will eventually lead to pulmonary emphysema. In addition, accumulation of polymers in hepatocytes causes liver diseases such as neonatal hepatitis, cirrhosis, and hepatocellular carcinoma.
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登,从1994开始制造检测抗体和蛋白质,主要侧重与病理学诊断有关的全套产品研发,既有纯化的重组蛋白和多肽,也有单抗和多抗,是世界一流的先天免疫领域的研究试剂制造商。