当前位置:
首页
>
产品中心 >
Tag_antibody >
Hycult Biotech/IL-13R-alpha-1, Mouse, mAb 1G3 | Hycult Biotech/HM1140-100UG
Hycult Biotech/IL-13R-alpha-1, Mouse, mAb 1G3 | Hycult Biotech/HM1140-100UG
商品编号:
HM1140-100UG
品牌:
hycultbiotech
市场价:
¥6340.00
美元价:
3804.00
产品分类:
标签抗体
公司分类:
Tag_antibody
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Mouse monoclonal antibody clone 1G3 recognizes mouse Il-13Ralpha1. Il-13 is a cytokine secreted by activated TH2 cells and is important mediator of allergic inflammation. Il-13 signals via interaction with a heterodimeric receptor of Il-4Rα and IL-13Rα. The IL13Rα consist of two cognate receptors, Il13-Rα1 and Il-13Rα2, which are expressed on a wide variety of cells among others B-cells, basophils, eosinophils, and macrophages. IL-13Rα1 is a glycosylated protein of ca 710KD. The receptor itself has a low affinity for IL13. However when paired with Il-4 it has a strong affinity for IL-13. After cytokine binding the receptor signals via JAK/STAT pathway. The heterodimeric receptor signal both with Il-13 and Il-4. Both cytokines have consequently quite comparable function. Il-13Rα2 and the recently discovered soluble Il-13Rα1 are thought to be decoy receptors for Il-13.Il-13 have been associated with diseases like asthma and idiopathic pulmonary fibrosis. Several studies have indeed shown the regulating role of Il-13 in airway hyper-reactivity leading to e.g. mucus secretion, chemokine production and IgE production. There are also indications that IL-13Rα1 is involved in macrophages differentiation and might serve as a biomarker for the M2 population.
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登,从1994开始制造检测抗体和蛋白质,主要侧重与病理学诊断有关的全套产品研发,既有纯化的重组蛋白和多肽,也有单抗和多抗,是世界一流的先天免疫领域的研究试剂制造商。
联络我们