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当前位置: 首页 > 产品中心 > Tag_antibody > Hycult Biotech/CRAMP, Mouse, mAb AC6-DH2 | Hycult Biotech/HM1125-100UG
商品详细Hycult Biotech/CRAMP, Mouse, mAb AC6-DH2 | Hycult Biotech/HM1125-100UG
Hycult Biotech/CRAMP, Mouse, mAb AC6-DH2  | Hycult Biotech/HM1125-100UG
Hycult Biotech/CRAMP, Mouse, mAb AC6-DH2 | Hycult Biotech/HM1125-100UG
商品编号: HM1125-100UG
品牌: hycultbiotech
市场价: ¥6980.00
美元价: 4188.00
产地: 美国(厂家直采)
公司:
产品分类: 标签抗体
公司分类: Tag_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
The monoclonal antibody AC6-DH2 recognizes the mouse protein Cathelin-Related AntiMicrobial Peptide (Cramp). Cathelicidins are a familiy of antimicrobial proteins predominantly found in the peroxidase-negative granules of neutrophils. the cathelicidins are synthesized as preproteins. Within the neutrophils, they are stored in granules as inactive proforms after removal of the signal peptide. The biologic active domains of the cathelicidins reside in the C-terminus. The C-terminal antimicrobial peptides are activated when cleaved from the proforms of the cathelicidins by serine proteases from azurophilic granules. Cramp (Cathelin-Related Anti-Microbial Peptide) is the mouse analogue of human LL-37 peptide, which is the antibacterial C-terminus of hCAP-18 (human cathelicidin). CRAMP forms an amphipathic α-helix similar to other antimicrobial peptides. Cramp is a potent antibiotic against Gram-negative bacteria by inhibiting growth of a variety of bacterial strains and by permeabilizing the inner membrane of E.coli directly. Abundant expression of Cramp is found in myeloid precursors and neutrophils. Cramp represents the first antibiotic peptide found in cells of myeloid lineage in the mouse. Inflammatory cells in the mouse can thus use a non-oxidative mechanism for microbial killing.
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登,从1994开始制造检测抗体和蛋白质,主要侧重与病理学诊断有关的全套产品研发,既有纯化的重组蛋白和多肽,也有单抗和多抗,是世界一流的先天免疫领域的研究试剂制造商。