当前位置:
首页
>
产品中心 >
monoclonal_antibody >
Hycult生物技术公司/Nectin-3,小鼠,单克隆抗体103-A1,FITC|Hycult生物技术公司/HM1053F-100UG
Hycult生物技术公司/Nectin-3,小鼠,单克隆抗体103-A1,FITC|Hycult生物技术公司/HM1053F-100UG
商品编号:
HM1053F-100UG
品牌:
hycultbiotech
市场价:
¥8860.00
美元价:
5316.00
产品分类:
单克隆抗体
公司分类:
monoclonal_antibody
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
The monoclonal antibody 103-A1 recognizes mouse nectin-3. Nectin-3 is a 83 kDa type Itransmembrane glycoprotein. Nectin, originally isolated as poliovirus receptor-related protein (PRR), isa cell-cell adhesion molecule of the immunoglobulin supergene family. Nectins are calciumindependentimmunoglobulin-like cell-cell adhesion molecules consisting of four members, nectin 1-4.Nectins homophilically and heterophilically trans-interact to form a variety of cell-cell junctions,including cadherin-based adherens junctions in epithelial cells and fibroblasts in culture, synapticjunctions in neurons, and Sertoli cell-spermatid junctions in testis, in cooperation with, orindependently of, cadherins. Both nectin-2 and nectin-3 are ubiquitously expressed, whereas nectin-1is abundantly expressed in brain. Nectin-2 and -3 are expressed in cells where cadherin is notexpressed, such as blood cells and spermatids. All members of the nectin family have two or threesplice variants. For nectin-3, three isoforms exist: nectin-3α, -3β and -3g of which nectin-3α is thelargest. Nectin-3, also known as PRR3, is a transmembrane protein that is predominantly expressedin testis and placental tissues as well in many cell lines. Nectin interacts in vivo with both long andshort isoforms of afadin, an actin binding protein, at cadherin-based cell-cell adherence junctions invarious tissues and cell lines. Furthermore, the ectodomains of nectin-3 and CD155 (PoliovirusReceptor) have shown strong affinity to each other.Injection of antibody 103-A1 into lumen of seminiferous tubules leads to disruption of the actinfilaments in Sertoli cells at the Sertoli-maturing spermatid ectoplasmic specialization and exfoliation ofmaturing spermatids form the seminiferous epithelium.
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登,从1994开始制造检测抗体和蛋白质,主要侧重与病理学诊断有关的全套产品研发,既有纯化的重组蛋白和多肽,也有单抗和多抗,是世界一流的先天免疫领域的研究试剂制造商。
联络我们