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当前位置: 首页 > 产品中心 > Tag_antibody > Hycult Biotech/SR-A, Mouse, mAb 2F8 | Hycult Biotech/HM1061-100UG
商品详细Hycult Biotech/SR-A, Mouse, mAb 2F8 | Hycult Biotech/HM1061-100UG
Hycult Biotech/SR-A, Mouse, mAb 2F8  | Hycult Biotech/HM1061-100UG
Hycult Biotech/SR-A, Mouse, mAb 2F8 | Hycult Biotech/HM1061-100UG
商品编号: HM1061-100UG
品牌: hycultbiotech
市场价: ¥6980.00
美元价: 4188.00
产地: 美国(厂家直采)
公司:
产品分类: 标签抗体
公司分类: Tag_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
The monoclonal antibody 2F8 recognizes mouse scavenger receptor class A (SR-A), type I and II, also known as CD204. SR-A belongs to the group of scavenger receptors, which are divided in class A, B, D and E. Class A scavenger receptors (SRs) are multi-domained membrane glycoproteins that can endocytose modified lipoproteins and bind a wide range of ligands. SR-A is expressed by tissue macrophages and functions both as an endocytic receptor for lipoproteins and as an adhesion receptor for macrophages binding to ligand rich tissues e.g. atherosclerotic lesions. Tissue macrophage- populations that express SR-A I and II include those of the marginal zone of the spleen, alveolar macrophages, heart and gut.SR-A binds bacterial pathogens and is considered to play a role in the innate immune response. TLR2 and TLR4 agonists synergistically up-regulate SR-A in RAW264.7 through p38 pathway. SR-A knockout mice are more susceptible to endotoxic shock than wild type mice, which suggests a role in the clearance of bacterial endotoxin from the circulation. Using thymic macrophages of the knockout mice as well as antibody treatment confirmed that SR-A is responsible for half of the phagocytic activity required for apoptotic thymocyte ingestion. Next to its role in innate immunity there is evidence that SR-A also contributes to acquired immune responses.Monoclonal antibody 2F8 recognizes an epitope within the αhelical coiled-coil domain of SR-A in all mouse strain tested, with the exception of C57BL/6. One amino-acid change (L168S), due to polymorphism, results in the loss of reactivity of antibody 2F8.
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登,从1994开始制造检测抗体和蛋白质,主要侧重与病理学诊断有关的全套产品研发,既有纯化的重组蛋白和多肽,也有单抗和多抗,是世界一流的先天免疫领域的研究试剂制造商。