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Hycult Biotech/CD71, Mouse, mAb ER-MP21 | Hycult Biotech/HM1085-100UG
Hycult Biotech/CD71, Mouse, mAb ER-MP21 | Hycult Biotech/HM1085-100UG
商品编号:
HM1085-100UG
品牌:
hycultbiotech
市场价:
¥4860.00
美元价:
2916.00
产品分类:
标签抗体
公司分类:
Tag_antibody
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
The monoclonal antibody ER-MP21 recognizes CD71, the transferrin receptor 1. CD71 is a 200 kDa glycoprotein composed of two identical, disulfide-linked chains. Each chain is capable of binding transferrin, an iron-transport molecule. Binding of transferrin to its receptor followed by endocytosis of the receptor-ligand complex is a major cellular iron-uptake mechanism. Iron uptake by the proliferating cell is essential for the iron-containing enzyme ribonucleotide reductase involved with DNA synthesis. CD71 is not only expressed by cycling cells, but also by cells that require iron for other iron-dependent proteins, such as the enzyme peroxidase in monocytes. Rapidly proliferating cells, as in malignancy, generally express CD71 abundantly. Furthermore, CD71 has been described as a marker of immature, proliferating T cells.The monoclonal antibody ER-MP21 inhibits proliferation and differentiation during early T cell development. ER-MP21 recognizes murine CD71, but does not compete with transferrin binding.
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登,从1994开始制造检测抗体和蛋白质,主要侧重与病理学诊断有关的全套产品研发,既有纯化的重组蛋白和多肽,也有单抗和多抗,是世界一流的先天免疫领域的研究试剂制造商。
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