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当前位置: 首页 > 产品中心 > Tag_antibody > Hycult Biotech/EMAPII, Mouse, mAb M7/1 | Hycult Biotech/HM1124-100UG
商品详细Hycult Biotech/EMAPII, Mouse, mAb M7/1 | Hycult Biotech/HM1124-100UG
Hycult Biotech/EMAPII, Mouse, mAb M7/1  | Hycult Biotech/HM1124-100UG
Hycult Biotech/EMAPII, Mouse, mAb M7/1 | Hycult Biotech/HM1124-100UG
商品编号: HM1124-100UG
品牌: hycultbiotech
市场价: ¥5620.00
美元价: 3372.00
产地: 美国(厂家直采)
公司:
产品分类: 标签抗体
公司分类: Tag_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Monoclonal antibody- clone M7/1 recognizes human endothelial-monocyte-activating polypeptide II (EMAP II). EMAPII is a proinflammatory cytokine and chemoattractant of macrophages and polymorphonuclear lymphocytes. The protein was initially identified as a product of murine methylcholanthrene A-induced fibrosarcoma cells. EMAP II is synthesized as a 34 kDa precursor molecule (proEMAP),- it can run anomalously in SDSpage at 43 kDa, and is enzymatically cleaved to produce a biologically active 22 kDa mature polypeptide. It modulates a range of properties of endothelial cells, monocytes, and neutrophils in vitro, and induces an acute inflammatory reaction and tumor regression in vivo. Later it was found to be anti-angiogenic and capable of induction of apoptosis in proliferation and hypoxic endothelial cells in vitro in tumor vasculature in vivo. EMAP II is released from cells, by a yet unknown mechanism, as pro- and mature EMAP II proteins in response to various forms of cellular stresses, including glucose starvation and hypoxia. Endothelial cells are the main target- for EMAPII and explain the anti-angiogenic property. The anti-tumor effect is expected to a large extent to be mediated through this characteristic. EMAPII is also associated with brain diseases and injury. EMAPII expression is related with leukocytes-infiltrated inflamed tissue and subsequent apoptosis. In solid tumors there is also an immunosuppressive role identified. EMAPII inducing tumor cells induce apoptosis of lymphocytes. EMPAII is considered a marker for microglial cells and macrophages in brain diseases. The distribution of EMAPII and its precursor in biopsies might be applicable as additive diagnostic tool.
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登,从1994开始制造检测抗体和蛋白质,主要侧重与病理学诊断有关的全套产品研发,既有纯化的重组蛋白和多肽,也有单抗和多抗,是世界一流的先天免疫领域的研究试剂制造商。