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Hycult Biotech/C5a/C5a des Arg, Human, mAb 2952 | Hycult Biotech/HM2079-100UG
Hycult Biotech/C5a/C5a des Arg, Human, mAb 2952 | Hycult Biotech/HM2079-100UG
商品编号:
HM2079-100UG
品牌:
hycultbiotech
市场价:
¥6340.00
美元价:
3804.00
产品分类:
标签抗体
公司分类:
Tag_antibody
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Monoclonal antibody 2952 reacts with a neo-epitope on C5a (des-Arg) that is formed upon cleavage of C5 into C5a and C5b. C5 is involved in the activation of the lythic pathway within the complement system which is an important factor in innate immunity. The complement pathways can be divided in the activation pathways and lytic pathway. The activation pathways lead via C3 to the cleavage of the fifth complement component C5. C5a induces smooth muscle contraction, increases vascular permeability, causes degranulation of mast cells and basophils, and release of lysosomal enzymes. In addition C5a stimulates the directed migration of neutrophils, eosinophils, basophils and monocytes. Recent studies indicate the modulation of the acute-phase response in liver and an overall immune response by inducing synthesis of cytokines such as TNF-alpha IL-1beta, IL-6 and IL-8. General comment: Please notice that under given conditions it is known that C5 can expose epitopes normally only found in the cleaved activation products (ref.5).
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登,从1994开始制造检测抗体和蛋白质,主要侧重与病理学诊断有关的全套产品研发,既有纯化的重组蛋白和多肽,也有单抗和多抗,是世界一流的先天免疫领域的研究试剂制造商。
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