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商品详细Hycult生物技术公司/MASP-1/3,人类,单克隆抗体2B11 | Hycult生物技术公司/HM2093-100UG
Hycult生物技术公司/MASP-1/3,人类,单克隆抗体2B11 | Hycult生物技术公司/HM2093-100UG
Hycult生物技术公司/MASP-1/3,人类,单克隆抗体2B11 | Hycult生物技术公司/HM2093-100UG
商品编号: HM2093-100UG
品牌: hycultbiotech
市场价: ¥8660.00
美元价: 5196.00
产地: 美国(厂家直采)
公司:
产品分类: 标签抗体
公司分类: Tag_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Three pathways of complement activation have been reported: the antibody-dependent classical pathway, the antibody-independent alternative pathway and the lectin pathway. Activation of each pathway involves formation of serine protease complexes, which results in activation of the central complement component C3. In the lectin pathway, mannose binding-lectin (MBL)-associated serine proteases (MASP) form complexes with polymeric lectin molecules which are involved in pattern recognition. Upon binding of the recognition molecules to carbohydrates on the surface of microorganisms, MASP are converted to their active forms and initiate complement activation. Three types of human MASP have been reported. MASP-1, MASP-2 and MASP-3.MASP-1 appears to cleave the second complement component C2, but not C4. The proteolytic activities of MASP-1 are inhibited by C1-inhibitor. Furthermore MASP-1 has a reactivity profile very similar to that of thrombin. MASP-1 is able to catalyse the formation of cross-linked fibrin. Participation of MASP-1 in cross-linked fibrin clot formation causes release of a chemotactic factor representing a biologically significant activity of MASP-1.The alternative-splicing product from MASP-1 gene is called MASP-3. MASP-1 is associated with smaller MBL oligomers whereas MASP-3 is found on larger oligomers. The substrate of MASP-3 is unknown.The antibody recognizes the heavy chain common to both MASP-1 and MASP-3.
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登,从1994开始制造检测抗体和蛋白质,主要侧重与病理学诊断有关的全套产品研发,既有纯化的重组蛋白和多肽,也有单抗和多抗,是世界一流的先天免疫领域的研究试剂制造商。