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当前位置: 首页 > 产品中心 > Tag_antibody > 海科生物技术公司/C5aR,人类,单克隆抗体S5/1 |海科生物技术公司/HM2094-100UG
商品详细海科生物技术公司/C5aR,人类,单克隆抗体S5/1 |海科生物技术公司/HM2094-100UG
海科生物技术公司/C5aR,人类,单克隆抗体S5/1 |海科生物技术公司/HM2094-100UG
海科生物技术公司/C5aR,人类,单克隆抗体S5/1 |海科生物技术公司/HM2094-100UG
商品编号: HM2094-100UG
品牌: hycultbiotech
市场价: ¥7820.00
美元价: 4692.00
产地: 美国(厂家直采)
公司:
产品分类: 标签抗体
公司分类: Tag_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
The monoclonal antibody S5/1 recognizes the human receptor for C5a (CD88). The C5a receptor- is a seven transmembrane GTP-binding-protein-coupled receptor of 45kDa which binds with high affinity to human anaphylatoxin C5a. Upon C5a binding- G-protein-dependent cellular- responses are initiated such as increased intracellular Ca2+, granule fusion with the cell membrane, enzyme release and oxidative burst suggesting that C5aR is an important mediator of inflammation. The C5a receptor is expressed on a broad range of cell types, including- neutrophils, monocytes/macrophages, dendritic cells, astrocytes and microglia.Interestingly, C5a receptor signalling has been associated with several inflammatory diseases including rheumatoid arthritis.-Clone S5/1 was raised against a synthetic peptide comprising the N-terminal domain of the C5aR (Met1-Asn31). The antibody has been shown to inhibit the binding of C5a to its receptor.
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登,从1994开始制造检测抗体和蛋白质,主要侧重与病理学诊断有关的全套产品研发,既有纯化的重组蛋白和多肽,也有单抗和多抗,是世界一流的先天免疫领域的研究试剂制造商。