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Hycult Biotech/MPO, Human, mAb 266-6K1 | Hycult Biotech/HM2164-100UG
Hycult Biotech/MPO, Human, mAb 266-6K1 | Hycult Biotech/HM2164-100UG
商品编号:
HM2164-100UG
品牌:
hycultbiotech
市场价:
¥5620.00
美元价:
3372.00
产品分类:
标签抗体
公司分类:
Tag_antibody
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
The monoclonal antibody 266-6K1 recognizes human myeloperoxidase (MPO), an ~135 glycoproteinexpressed in all cells of the myeloid linage. MPO functions as an α2β2 heteromultimer consisting oftwo heavy (α) and two light (β) chains of 55 and 15 kDa respectively. MPO is abundantly present inazurophilic granules of polymorphonuclear neutrophils (PMNs). It is an important enzyme used duringphagocytic lysis of engulfed foreign particles which takes part in the defense of the organism throughproduction of hypochlorous acid (HOCl), a potent oxidant. In the stimulated PMN, MPO catalyzes theproduction of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxicintermediates that greatly enhance PMN microbicidal activity. Upon activation of neutrophils, MPO canbe rapidly released and as such useful in body fluids as marker for inflammatory status.Involvement of MPO has been described in numerous diseases such as atherosclerosis, lung cancer,Alzheimer"s disease, inflammatory bowel disease and multiple sclerosis. Autoimmune antibodies toMPO (so called ANCA) are involved in Wegener’s disease. Since the discovery of MPO deficiency,initially regarded as rare and restricted to patients suffering from severe infections, MPO has attractedmore clinical attention.
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登,从1994开始制造检测抗体和蛋白质,主要侧重与病理学诊断有关的全套产品研发,既有纯化的重组蛋白和多肽,也有单抗和多抗,是世界一流的先天免疫领域的研究试剂制造商。
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