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当前位置: 首页 > 产品中心 > Sandwich_method_ELISA > 海科生物科技/TLR4,人类,单克隆抗体4D9 |海科生物科技/HM2298-20UG
商品详细海科生物科技/TLR4,人类,单克隆抗体4D9 |海科生物科技/HM2298-20UG
海科生物科技/TLR4,人类,单克隆抗体4D9 |海科生物科技/HM2298-20UG
海科生物科技/TLR4,人类,单克隆抗体4D9 |海科生物科技/HM2298-20UG
商品编号: HM2298-20UG
品牌: hycultbiotech
市场价: ¥1980.00
美元价: 1188.00
产地: 美国(厂家直采)
公司:
产品分类: 夹心法ELISA
公司分类: Sandwich_method_ELISA
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
The monoclonal antibody 4D9 reacts with the Toll-like receptor 4 (TLR4, CD284). TLRs are expressed by various cells of the immune system, such as macrophages and dendritic cells. TLRs are class I receptors, with a single α-helix that spans the cell membrane. They recognize and respond to molecules derived from bacterial, viral and fungal pathogens, such as lipopolysaccharide (LPS) from the outer membrane of Gram negative bacteria, peptidoglycan fragments from bacterial cell walls and single-stranded and double-stranded RNA from viruses.Toll-like receptor 4 has been identified, next to MD-2 and CD14, as a receptor that is central to the innate immune response to LPS of Gram-negative bacteria. The extracellular TLR4 domain alone cannot bind to LPS, only the TLR4-MD-2 complex is capable of binding LPS. TLR4 is unique among TLRs in its ability to activate two distinct signaling pathways; one pathway is activated by the adaptors TIRAP (Toll/interleukin-1- receptor (TIR)-domain-containing adaptor protein) and MyD88, which leads to the induction of pro inflammatory cytokines. The second pathway is activated by the adaptors TRIF (TIR-domaincontaining adaptor protein inducing interferon β) and TRAM (TRIFrelated adaptor molecule), which leads to the induction of type I interferons.The monoclonal antibody 4D9 reacts with the extracellular part of the receptor. A few studies report the existing of soluble TLR4. This antibody should be able to recognize this protein.
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登,从1994开始制造检测抗体和蛋白质,主要侧重与病理学诊断有关的全套产品研发,既有纯化的重组蛋白和多肽,也有单抗和多抗,是世界一流的先天免疫领域的研究试剂制造商。