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当前位置: 首页 > 产品中心 > Tag_antibody > 海科生物技术/JAM-A,人类,单克隆抗体M.Ab.F11,功能研究抗体,低内毒素|海科生物技术/HM2099-500UG
商品详细海科生物技术/JAM-A,人类,单克隆抗体M.Ab.F11,功能研究抗体,低内毒素|海科生物技术/HM2099-500UG
海科生物技术/JAM-A,人类,单克隆抗体M.Ab.F11,功能研究抗体,低内毒素|海科生物技术/HM2099-500UG
海科生物技术/JAM-A,人类,单克隆抗体M.Ab.F11,功能研究抗体,低内毒素|海科生物技术/HM2099-500UG
商品编号: HM2099-500UG
品牌: hycultbiotech
市场价: ¥26820.00
美元价: 16092.00
产地: 美国(厂家直采)
公司:
产品分类: 标签抗体
公司分类: Tag_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
The monoclonal antibody M.Ab.F11 recognizes junctional adhesion molecule-A (JAM-A) also known as the human platelet F11-Receptor (F11R) and JAM-1 is a cell adhesion molecule (CAM). JAM-A is a member of the immunoglobulin superfamily found on the surface of human platelets and at intercellular junctions of endothelial cells and epithelial cells. JAM-A belongs together with JAM-C (JAM-2) and JAM-B (VE-JAM or JAM-3) to a family of adhesion proteins with a V-C2 immunoglobulin domain organization. JAM plays an important role in tight junctions where it is involved in cell-to-cell adhesion through homophilic interaction. It codistributes with other tight junction components as ZO-1, 7H6 antigen, cingulin and occludin. JAM-A plays a role in platelet aggregation, secretion, adhesion, spreading.In the platelet F11R/JAM-A is a membrane protein involved in 2 distinct processes initiated on the platelet surface. Antibody-induced platelet aggregation and secretion both dependent on FcgammaRII and GPIIb/IIIa integrin, a process that may be involved in pathophysiological processes associated with certain thrombocytopenias. Antibody mediated platelet adhesion independent from FcgammaRII or fibrinogen receptor and that appears to play a role in physiological processes associated with platelet adhesion and aggregation. A physiological role for the F11R/JAM-A protein was demonstrated by its phosphorylation after the stimulation of platelets by thrombin and collagen. A pathophysiological role for the F11R/JAM-A was revealed by demonstrating the presence of F11R/JAM-A antibodies in patients with thrombocytopenia. Adhesion of platelets through the F11R resulted in events characteristic of the action of cell adhesion molecules (CAMs). Recent data suggests a role for F11R/JAM-A in the adhesion of platelets to cytokine-inflamed endothelial cells and thus in thrombosis and atherosclerosis induced in non-denuded blood vessels by inflammatory processes.
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登,从1994开始制造检测抗体和蛋白质,主要侧重与病理学诊断有关的全套产品研发,既有纯化的重组蛋白和多肽,也有单抗和多抗,是世界一流的先天免疫领域的研究试剂制造商。