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当前位置: 首页 > 产品中心 > Polyclonal_antibody > Hycult Biotech/Chlorotyrosine, pAb | Hycult Biotech/HP5002-20UG
商品详细Hycult Biotech/Chlorotyrosine, pAb | Hycult Biotech/HP5002-20UG
Hycult Biotech/Chlorotyrosine, pAb  | Hycult Biotech/HP5002-20UG
Hycult Biotech/Chlorotyrosine, pAb | Hycult Biotech/HP5002-20UG
商品编号: HP5002-20UG
品牌: hycultbiotech
市场价: ¥1980.00
美元价: 1188.00
产地: 美国(厂家直采)
公司:
产品分类: 多克隆抗体
公司分类: Polyclonal_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
The polyclonal antibody recognizes 3-chlorotyrosine specific protein adducts that are formed by hypochlorous acid. Polymorphonuclear leukocytes or neutrophils are one of the primary defense mechanisms against invading microorganisms and also involved in the removal of necrotic cells. However, in certain conditions, recruitment of neutrophils may aggravate existing injury. For example, neutrophils are involved in the pathophysiology of hepatic ischemia-reperfusion injury, endotoxin- and sepsis-induced liver failure, alcoholic hepatitis, and certain drug toxicities. The fact that neutrophils accumulate in the liver does not necessarily mean that they cause injury. ICAM-1 and CD18 integrins are involved in the adherence of neutrophils to target cells, e.g., hepatocytes. This results in a long-lasting adherence-dependent oxidant stress, which is a major factor in neutrophil-mediated liver cell killing. Stimulated neutrophils release oxidants, proteases, and other potentially injurious constituents. They generate superoxide radicals and hydrogen peroxide and release MPO, which catalyzes oxidation of chloride by hydrogen peroxide to give hypochlorous acid. This hypochlorous acid can react with proteins to form 3-chlorotyrosine protein adducts. A limitation for investigating the pathophysiological role of neutrophils in vivo is the lack of a reliable biomarker for neutrophil cytotoxicity. Immunohistochemical staining of liver samples with anti 3-chlorotyrosine antibody correlates well with neutrophil-induced liver injury.The polyclonal antibody can be used to assess chlorotyrosine protein adduct formation and is a useful marker of neutrophil-induced liver cell injury in vivo.
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登,从1994开始制造检测抗体和蛋白质,主要侧重与病理学诊断有关的全套产品研发,既有纯化的重组蛋白和多肽,也有单抗和多抗,是世界一流的先天免疫领域的研究试剂制造商。