海科生物科技/C9，人类，天然|海科生物科技/HC2142
商品编号：
HC2142
品牌：
hycultbiotech
市场价：
¥7200.00
美元价：
4320.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Glycoprotein complement factor C9 is synthesized as a single chain protein of 558AA and is present in human serum at ca 60ug/ml. C9 is predominantly formed in the liver, but is also synthesized by monocytes, macrophages, fibroblasts and glial cells. Pore forming proteins with a membrane-attack complex perforin domain (MACPF) are most effective to kill bacteria or virus infected cells. The MACPF domain polymerizes, refolds and inserts itself into the bilayer membrane. C5b binds to the membrane and binds C6&7. The addition of C8 to the complex triggers and accelerates C9 polymerization in order to form the asymmetric pore on the target surface. A complete pore can exist out of 12-18 C9 monomers. Together with CD59, MAC formation is regulated by eg DAF, MCP and CR1. C9 deficiency is quite common, especially in the Japanese population. These patients are more susceptible for bacterial infection.
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。
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