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当前位置: 首页 > 产品中心 > Polyclonal_antibody > 海科生物技术公司/SAP,人类,pAb |海科生物技术公司/HP9055-20UG
商品详细海科生物技术公司/SAP,人类,pAb |海科生物技术公司/HP9055-20UG
海科生物技术公司/SAP,人类,pAb |海科生物技术公司/HP9055-20UG
海科生物技术公司/SAP,人类,pAb |海科生物技术公司/HP9055-20UG
商品编号: HP9055-20UG
品牌: hycultbiotech
市场价: ¥1980.00
美元价: 1188.00
产地: 美国(厂家直采)
公司:
产品分类: 多克隆抗体
公司分类: Polyclonal_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
The polyclonal antibody recognizes serum amyloid P (SAP). Serum amyloid P component (SAP)belongs to a highly conserved superfamily of calcium-dependent ligand binding and lectin(carbohydrate binding) proteins. Due to the pentameric structure these proteins are also calledpentraxins. SAP is 25kDa in size. C-reactive protein (CRP) and SAP are well-charactarized shortpentraxins, which are produced in the liver in response to inflammatory mediators. Pentraxin 3 (PTX3)is the prototypic long pentraxin. Both SAP and CRP are evolutionary conserved in all vertebrates andfound in distant invertebrates such as the horseshoe crab (Limulus polyphemus). They share 51%residue sequence identity and 66% homology.SAP is highly resistant to proteolysis, especially when it forms complexes with calcium-dependentligands. SAP avidly binds to macromolecular ligands, such as nucleosomal DNA, glycosaminoglycansand amyloid fibrils. When aggregated it can bind C1q and activate the classical complement pathway.Human SAP is not an acute phase reactant following acute stimuli, this in contrast to mouse SAP andhuman CRP. In mouse, SAP levels increase significantly 24 hours after challenge withlipopolysaccharide.SAP is a normal plasma constituent that is present in cerebrospinal fluid (CSF), in the pathognomoniclesions of Alzheimer"s disease (AD), cerebrovascular and intracerebral Aβ amyloid plaques andneurofibrillary tangles. This is a result of its binding to amyloid fibrils and to paired helical filaments,respectively. The protein itself may also be directly neurocytotoxic. SAP contributes significantly to thepathogenesis of amyloidosis. The mechanism of its participation is not yet known and importantly maydiffer between species.The normal human serum level of SAP is 30-40 μg/ml. One study described that the mean SAPconcentration in serum of women (24 μg/ml) is significantly lower than in men (32 μg/ml). Theconcentration does not alter significantly after major surgery and is only slightly increased duringchronic active diseases. Significantly low levels of SAP are only seen in patients with severehepatocellular impairment which reduces plasma protein synthesis. In cerebrospinal fluid (CSF), themean level of SAP in healthy individuals is 8.5 ng/ml
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登,从1994开始制造检测抗体和蛋白质,主要侧重与病理学诊断有关的全套产品研发,既有纯化的重组蛋白和多肽,也有单抗和多抗,是世界一流的先天免疫领域的研究试剂制造商。