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主营:主营:病理学诊断相关的抗体,蛋白质
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当前位置: 首页 > 产品中心 > Polyclonal_antibody > Hycult Biotech/IL-12B p40,人,pAb | Hycult Biotech/HP9072
商品详细Hycult Biotech/IL-12B p40,人,pAb | Hycult Biotech/HP9072
Hycult Biotech/IL-12B p40,人,pAb | Hycult Biotech/HP9072
Hycult Biotech/IL-12B p40,人,pAb | Hycult Biotech/HP9072
商品编号: HP9072
品牌: hycultbiotech
市场价: ¥4700.00
美元价: 2820.00
产地: 美国(厂家直采)
公司:
产品分类: 多克隆抗体
公司分类: Polyclonal_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
This polyclonal antibody is directed against the interleukin 12 (IL-12) subunit IL12B. IL-12 is a key immunoregulatory cytokine that coordinates innate and adaptive immune responses. IL12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit IL12B, and a 35 kD subunit IL12A. IL12 is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. It acts on T and natural killer cells, and has a broad array of biological activities. The main role of IL-12 is activation of Interferon gamma ( IFN-gamma) production by triggering the Jak-STAT signaling pathway. Overexpression of the IL12 gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. IL-12 is also linked to autoimmunity. Promoter polymorphisms in the IL12 gene have been reported to be associated with the severity of atopic and non-atopic asthma in children.
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登,从1994开始制造检测抗体和蛋白质,主要侧重与病理学诊断有关的全套产品研发,既有纯化的重组蛋白和多肽,也有单抗和多抗,是世界一流的先天免疫领域的研究试剂制造商。