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商品详细海科生物技术公司/眼镜蛇毒液因子,重组|海科生物技术公司/HC4073
海科生物技术公司/眼镜蛇毒液因子,重组|海科生物技术公司/HC4073
海科生物技术公司/眼镜蛇毒液因子,重组|海科生物技术公司/HC4073
商品编号: HC4073
品牌: hycultbiotech
市场价: ¥8180.00
美元价: 4908.00
产地: 美国(厂家直采)
公司:
产品分类: 多肽
公司分类: peptides
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
HC4073 is the recombinant form of Cobra venom factor (CVF). The complement system is the first line of defenseagainst pathogens and important component of innate as well as adaptive immunity. CVF is the non-toxic complementactivating protein in the venom from the cobra species Naja Kaouthia. CVF is a structural and functional analog ofcomplement C3. The protein functionally resembles C3b and exhibits a three-chain structure like C3c. CVF forms aC3/C5 convertase with factor B in the presence of factor D and Mg2+, thereby activating the alternative pathway ofcomplement. Although analog in function, there are two differences between CVF,Bb convertases and natural C3b,Bbconvertases. First the stability is quite different. Whereas C3b,Bb is short-lived with a half-life of 1.5 min, CVF,Bb israther stable with a half-life of 7h. Secondly, factor H disassembles C3b,Bb and serves as cofactor for proteolyticinactivation of C3b by factor I. The CVF convertase is completely resistant to factor H and I. Which makes it an excellent research tool. CVF is widely used reagent in order to deplete serum samples in order to study the role of complement in host defense, immune response and pathogenesis of disease. Since the Naja species are on the list of endangered species, native CVF will increasingly difficult to obtain. The recombinant protein (rCVF)is synthesized in insect cells and is processed into a two-chain form of pro-CSF that structurally resembles C3 (Vogel et al). Pro-CVF can present in three forms and have all functional activity of mature, native CVF. The activity of pro-CVF and the resulting convertase isindistinguishable from CVF and the C3b,Bb convertase. rCVF can be exploited in vitro as well as in animals. This leadsto decomplemented serum and high concentration of complement end products, like C3a, C5a and sTCC.
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登,从1994开始制造检测抗体和蛋白质,主要侧重与病理学诊断有关的全套产品研发,既有纯化的重组蛋白和多肽,也有单抗和多抗,是世界一流的先天免疫领域的研究试剂制造商。