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Hycult Biotech/TFPI, Human, mAb CLB TFPI Kunitz-2 | Hycult Biotech/HM2352
Hycult Biotech/TFPI, Human, mAb CLB TFPI Kunitz-2 | Hycult Biotech/HM2352
商品编号:
HM2352
品牌:
hycultbiotech
市场价:
¥5620.00
美元价:
3372.00
产品分类:
单克隆抗体
公司分类:
monoclonal_antibody
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Antibody CLB/TFPI KUNITZ-2 recognizes the Kunitz domain 2 (aa 88-160)of TFPI. TFPI (tissue factor pathway inhibitor) is a is a single-chain polypeptide serine protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. TFPI is known to interact and inhibit the activated factor X and VIIa-TF proteases in an autoregulatory loop. TFPI is a dual inhibitor, binding to the TF/FVIIa complex to prevent it from acting on its FIX and FX substrates, and by directly inhibiting FXa. Inadequate down-regulation of FXa function by TFPI deficiency leads to thrombosis. Besides coagulation, TFPI may play additional roles in innate immunity, microbial defense, inflammation, angiogenesis, lipid metabolism, and cellular signaling, proliferation, migration and apoptosis.Tissue factor pathway inhibitor (TFPI) Kunitz-2 is a multivalent, Kunitz-type proteinase inhibitor, which, due to alternative mRNA splicing, is transcribed in three isoforms: TFPIalpha, TFPIdelta, and glycosyl phosphatidyl inositol (GPI)-anchored TFPIbeta. The microvascular endothelium is thought to be the principal source of TFPI and TFPIalpha is the predominant isoform expressed in humans. TFPI consists of an acidic aminoterminal polypeptide, followed by 3 tandem Kunitz-type domains (Kunitz domains 1, 2, and 3) and a basic carboxyterminal tail. The Kunitz domains are the active protease inhibiting domains of TFPI. The domains are relatively small with a length of about 50 to 60 amino acids and a molecular weight of 6 kDa. TFPI exerts its anticoagulant function by inhibiting tissue factor (TF)–induced coagulation in the blood. The Kunitz-2 domain of TFPI is responsible for factor Xa inhibition.
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登,从1994开始制造检测抗体和蛋白质,主要侧重与病理学诊断有关的全套产品研发,既有纯化的重组蛋白和多肽,也有单抗和多抗,是世界一流的先天免疫领域的研究试剂制造商。
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