杂交生物技术/uPAR（D2结构域），人，单克隆抗体IIIB11/HM2143/100µg
商品编号：
HM2143
品牌：
hycultbiotech
市场价：
¥6432.00
美元价：
3859.20
产品分类：
单克隆抗体
公司分类：
monoclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Description:uPAR(D2domain),Human,mAbIIIB11
MonoclonalantibodyIIIB11recognizestheurokinase-typeplasminogenactivatorreceptor(uPARorCD87),aGPIanchoredhighlyglycosylated,single-chainpolypeptide.CD87,a45-to60-kDprotein,consistsofthreestructurallyhomologousdomainsofapproximately90aminoacids,designatedD1,D2,andD3,eachcontainingaconservedarrangementofdisulfidebondsandseparatedbyshortinterdomainlinkersequences.uPARexistsinvariousmolecularforms;heavilyglycosylated,acleavedform,asolubleformandsplicedforms.CD87isexpressedbymonocytes/macrophages,neutrophils,endothelial,smoothmusclecellsandepithelialcells.CD87isoverexpresseduponexposuretoinflammatorymediators.Theproteinisalsohighlyexpressedbytumorcellsandcontributestotheirinvasivenessandmetastaticpotential.CD87isamultiligandreceptorthatoperatesasakeyelementinpathophysiologicalprocessesinvolvingcellmigrationandtissueremodellingduringinflammationandcancermetastasis.CD87bindswithhighaffinitytheSer-proteinaseurokinase-typeplasminogenactivator(uPA)which,uponbindingcatalyzestheconversionofplasminogenintoplasminwhichactivatesvariousmatrixmetalloproteinaseleADIngtoahighpotentialforpericellularproteolysis.CD87functionsalsoasanadhesionmoleculebybindingvitronectin,thuscontributingtoleukocyticadherence.High-affinitybindingofCD87tobothuPAandvitronectinrequiresthepresenceofdomain1(D1).Yet,CD87participatesincelladherenceandmigrationalsothroughtwootherroutes,aphysicalassociationandfunctionalinteractionwithvariousintegrinsandviaanintrinsicchemotacticactivityassociatedtotheD1-D2linkersequence.MonoclonalantibodyIIIB11recognizesD2oftheurokinase-typeplasminogenactivatorreceptor(CD87).Theantibodyrecognizesaminoacidsequences125-132oftheD2domain.
Specifications:
| Catalognumber | HM2143 |
|---|---|
| Producttype | Monoclonalantibodies |
| Quantity | 100µg |
| Formulation | 1ml(100μg/ml)0.2μmfilteredantibodysolutioninPBS,containing0.1%bovineserumalbuminand0.02%sodiumazide. |
| Application | Flowcytometry,Frozensections,Paraffinsections,Westernblot |
| Use | Forimmunohistochemistry,flowcytometryandWesternblottingdilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:10. |
| Isotype | MouseIgG1 |
| Species | Human |
| Alias | uPA,CD87,ClusterofDifferentiation87 |
| References | 1.Luther,Tetal;Epitope-mappedmonoclonalantibodiesastoolsforfunctionalandmorphologicalanalysesofthehumanurokinasereceptorintumortissue.AmJPathol1997,150:1231 |
| StorageandstABIlity | Productshouldbestoredat4°C.Underrecommendedstorageconditions,productisstableforatleastoneyear.Theexactexpirydateisindicatedonthelabel. |
| Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandfederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultfromtheuseorderivationofthisproduct. |
| Disease | Tumorimmunology |
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。
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