海科生物技术/MG-H1,单克隆抗体1H7G5 |海科生物技术/HM5017
商品编号:
HM5017
品牌:
hycultbiotech
市场价:
¥6980.00
美元价:
4188.00
产品分类:
单克隆抗体
公司分类:
monoclonal_antibody
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
The MG-H1 antibody clone 1H7G5 recognizes methylglyoxal 5-hydro-5-methylimidazolones (MG-H1). Glycation, or nonenzymatic glycation, is the nonenzymatic reaction of glucose and other reducing sugars with free amino groups of proteins, lipids and nucleic acids. The amino groups of the side chains of arginine and lysine are the primary targets for this type of modification. Over time, the initial glycation products may undergo intramolecular rearrangements and oxidation reactions (glycoxidation) and ultimately transfrom in stable, so-called advanced glycation end products (AGEs). Several compounds, e.g. NƐ-carboxymethyl-lysine (CML), pentosidine, or methylglyoxal (MGO) derivates, serve as examples of well-characterized and widely studies AGEs. AGEs have the potential to interact with a specific receptor (RAGE), a member of the immunoglobulin superfamily, initiating signal pathways that amplify inflammation and oxidative stress, and thereby leading to cellular injury and death. High levels of circulating AGEs are associated with cardiovascular disease, diabetes, chronic kidney disease, and increased mortality. Methylglyoxal (MGO) is an endogenous product of glucose metabolism. Increased production and accumulation of MGO, as well as increased modification of proteins by glycoxidation, are hallmarks of aging and diabetes. MGO was shown to modify proteins and to contribute to the accumulation of damaged proteins that can be toxic to cells. Besides argpyrimidine and tetrahydropyrimidine, methylglyoxal hydroimidazolones (MG-Hs) comprise the most prevalent arginine-derived AGE. They are formed as a mixture of three isomers by protein glycation with MGO. MG-Hs are estimated to modify 1–2% of all arginine residues found in lens proteins of elderly human subjects. Levels of this AGE have also been found to be elevated in patients with cardiovascular disease, Alzheimer’s disease, and diabetes mellitus.
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登,从1994开始制造检测抗体和蛋白质,主要侧重与病理学诊断有关的全套产品研发,既有纯化的重组蛋白和多肽,也有单抗和多抗,是世界一流的先天免疫领域的研究试剂制造商。
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