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当前位置: 首页 > 产品中心 > monoclonal_antibody > Hycult Biotech/NF-kB p65, Human, mAb 14H2 | Hycult Biotech/HM2345
商品详细Hycult Biotech/NF-kB p65, Human, mAb 14H2 | Hycult Biotech/HM2345
Hycult Biotech/NF-kB p65, Human, mAb 14H2  | Hycult Biotech/HM2345
Hycult Biotech/NF-kB p65, Human, mAb 14H2 | Hycult Biotech/HM2345
商品编号: HM2345
品牌: hycultbiotech
市场价: ¥5620.00
美元价: 3372.00
产地: 美国(厂家直采)
公司:
产品分类: 单克隆抗体
公司分类: monoclonal_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Mouse monoclonal antibody 14H2 recognizes human Nuclear factor- kB (NF-kB )p65, also called RelA-p65. NF-kB is considered to be one of the main transcription factors driving the expression of genes of inflammatory and immune responses, regulated by a divers panel of modifications to exerts it divers function. Other family members in mammals are RelB, c-Rel, NF-kB1 and NF-kB2, the latter two are processed in respectively p105/p50 and p100/p52. NF-kB functions as a dimer and they all share a Rel homology domain, responsible for DNA binding and dimerization. The activity of NF-kB is regulated by interaction with a family of inhibitory IkB proteins. The different NF-kB complexes have their own individual IkB proteins. In general NF-kB is present as IkB -complex in the cytoplasm. When the inflammatory response is triggered by eg proinflammatory cytokines or LPS, this leads to phosphorylation of IkB via IKK complex (IKKα, IKKβ and NEMO) leading to release of NF-kB from the complex. Subsequently, NF-kB enters the nucleus where it activates gene expression. NF-kB activation consist out of two activation pathways. The canonical pathway is the most common one. In the canonical pathway, IκBα is phosphorylated in an IKKβ- and NEMO-dependent manner, which results in the nuclear translocation of mostly p65-containing heterodimers. In contrast, the non-canonical pathway involves IKKα-mediated phosphorylation of p100 associated with RelB, which leads to partial processing of p100 and the generation of transcriptionally active p52-RelB complexes. Besides inflammation, auto-immune and metabolic diseases, NF-kB is involved in tumor development. Related inflammatory diseases are IBD, rheumatoid arthritis, SLE, diabetis, celiac disease, multiple sclerosis and Parkinson’s disease.
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登,从1994开始制造检测抗体和蛋白质,主要侧重与病理学诊断有关的全套产品研发,既有纯化的重组蛋白和多肽,也有单抗和多抗,是世界一流的先天免疫领域的研究试剂制造商。