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当前位置: 首页 > 产品中心 > monoclonal_antibody > Hycult Biotech/RNAse 7, Human, mAb 3C2 | Hycult Biotech/HM2316
商品详细Hycult Biotech/RNAse 7, Human, mAb 3C2 | Hycult Biotech/HM2316
Hycult Biotech/RNAse 7, Human, mAb 3C2  | Hycult Biotech/HM2316
Hycult Biotech/RNAse 7, Human, mAb 3C2 | Hycult Biotech/HM2316
商品编号: HM2316
品牌: hycultbiotech
市场价: ¥7820.00
美元价: 4692.00
产地: 美国(厂家直采)
公司:
产品分类: 单克隆抗体
公司分类: monoclonal_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Monoclonal antibody 3C2 recognizes human RNAse7. Antimicrobial proteins (AMP) are a fundamental element of the primary response against pathogens. AMPs are small endogenous cationic molecules expressed by phagocytic and epithelial cells. The antimicrobial activity of AMPs is directed towards a broad spectrum of pathogens, like Gram-positive & negative bacteria, viruses, yeast and fungi. AMPs aid in innate and adaptive immunity via direct inactivation and by immunomodulatory activity like leukocyte migration. RNAse 7 is an protein secreted by a variety of epithelial tissues and is a member of the RNAse A superfamily. This family shares sequence and structural similarities such as conserved cysteine residues as well as conserved histidines and a lysine in the active center catalysing the ribonuclease activity. RNAse7 is a 14.5 KDa protein with distinct ribonuclease activity. However, the antimicrobial activity is independent form the ribonuclease activity which might be associated with antiviral activity. On a per molar basis, RNAse7 is one of the most potent AMP. RNAse7 contributes to the sterility in several systems. It is described to be important in sterility of the kidney and urinary tract as well as its contribution to the skin barrier protection. In the urinary system it is constitutively expressed by the intercalated cells in the renal collecting tubules and is present in the urine at such levels to kill bacteria at baseline. In the skin it contributes to control the growth of microorganisms on the skin surface, and the expression levels can be further induced under control of proinflammatory cytokines. The bactericidal activity of RNAse7 has been associated with its ability to bind and permeate the bacterial cell membrane. This requires clustering of lysine residues. RNAse7 is able to bind LPS and peptidoglycans. In ocular surface, signal transduction associated with RNAse7expression is mediated via MAPKs but not NF-κB signalling pathways. IL1β leads to an increased expression of RNAse7.
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登,从1994开始制造检测抗体和蛋白质,主要侧重与病理学诊断有关的全套产品研发,既有纯化的重组蛋白和多肽,也有单抗和多抗,是世界一流的先天免疫领域的研究试剂制造商。