Hycult Biotech/C9, Mouse, mAb C9-6-25-5/HM1134/100 µg
商品编号：
HM1134
品牌：
hycultbiotech
市场价：
¥7752.00
美元价：
4651.20
产品分类：
单克隆抗体
公司分类：
monoclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Description:C9,Mouse,mAbC9-6-25-5
ThemonoclonalantibodyC9-5-48recognizesmousecomplementcomponentC9.Thecomplementsystemisanancientproinflammatoryandmicrobialdestructionsystem,thatmaybeconsideredpartofboththeinnateandadaptiveimmunesystems.Itconsistsoftheclassical,alternative,andlectin-bindingpathways.Eachpathwayistriggeredinadistinctmanner,yetalldepositC3fragmentsonatargetandengageacommonterminalsequencecalledTCCorthe"membraneattackcomplex"(MAC).Incontrasttotheactivationpathways,whichrequireenzymaticcleavageforactivation,theterminalpathwayreliesonconformationalchangesinducedbybindingofthedifferentsubunits.TCCiscomposedofacomplexoffourcomplementproteins(C5b,C6,C7,andC8)whichbindtotheoutersurfaceofthetargetplasmamembrane,andmanycopiesofafifthprotein(C9)thathookuptooneanother,formingaringinthemembrane.TheringstructureformedbyC9isaporeinthemembranethatallowsfreediffusionofmoleculesinandoutofthecell.Ifenoughporesform,thecellisnolongerabletosurvive.Themembraneattackcomplexisinitiatedwhenthecomplementprotein,C5convertase,cleavesC5intoC5aandC5b.BindingofC6facilitatesbindingofC7whichalterstheconformationofthecomplex.AfterbindingofC8,avariablenumberofC9moleculesassociatewiththeC5b678complex,togetherconstitutingTCC.TheformationofTCCcauseslysisofcellsorcantriggeravarietyofcellularmetabolicpathwaysresultinginthesynthesisandreleaseofinflammatorymediators.
Specifications:
| Catalognumber | HM1134 |
|---|---|
| Producttype | Monoclonalantibodies |
| Quantity | 100µg |
| Formulation | 1ml(100µg/ml)0.2µmfilteredantibodysolutioninPBS,containing0.1%bovineserumalbuminand0.02%sodiumazide. |
| Application | Westernblot |
| ApplicationNotes | W:AreducedsampletreatmentandSDS-Pagewasused.Thebandsizeis72kDa. |
| Use | ForWesternblottingdilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50. |
| Immunogen | MurineC9peptide |
| Isotype | RatIgG2a |
| Species | Mouse |
| StorageandstABIlity | Productshouldbestoredat4°C.Underrecommendedstorageconditions,productisstableforatleastoneyear.Theexactexpirydateisindicatedonthelabel. |
| Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandfederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultfromtheuseorderivationofthisproduct. |
| Disease | Infectiousdiseases,Nephrology |
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。
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