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Hycult Biotech/Pentraxin 3, Mouse, mAb 6B11, biotinylated/HM1131BT/50 µg
Hycult Biotech/Pentraxin 3, Mouse, mAb 6B11, biotinylated/HM1131BT/50 µg
商品编号：
HM1131BT
品牌：
hycultbiotech
市场价：
¥4896.00
美元价：
2937.60
产品分类：
单克隆抗体
公司分类：
monoclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Description:Pentraxin3,Mouse,mAb6B11,biotinylated
Monoclonalantibody6B11recognizesmousepentraxin3(PTX3).Thefirstlineofdefenseagainstpathogensisrepresentedbytheinnateimmunesystem.Animportantpartofthissystemistherecognitionofpathogenassociatedmolecularpatterns(PAMPs)bypatternrecognitionmolecules(PRMs).Pentraxins(PTXs)areafamilyofsolublecyclicpentamericPRMs.Basedonprimarystructure,theycanbedividedintwogroups,shortandlongPTXs.C-reactiveprotein(CRP)andserumamyloidPcomponent(SAP)areprototypicshortPTXs.OthershavebeenclassifiedaslongPTXs.PTXshaveaconservedca200aminoacidlongc-terminaldomaincontainingthePTXsignature(HxCxS/TWxS,wherexisanyaminoacid).HumanPTX3encodesa381aminoacid,45kDasecretoryglycoproteinwitha162aminoacidN-terminalextensionanda202aminoacidC-terminalpentraxindomain.Thereisalsoahighdegreeofconservationbetweenfrommousetoman.PTX3istheprototypiclongPTXandwasoriginallyidentifiedinendothelialcellsandfibroblasts.OrthologsofPTX3havebeenfoundinavarietyofspecies.ThePTX3geneconsistsofthreeexonsandtwointrons.ThefirsttwoexonscodefortheleaderpeptideandtheN-terminaldomainoftheprotein,respectively,andthethirdexonencodesthepentraxindomain.PTX3expressioncanamongothersbeinducedbyproinflammatorycytokineslikeTNFα,Il1βandTLRagoNISTs.WhereasshortPTXsareproducedintheliver,themainsourceofPTX3expressionaremyeloiddendriticcellsbutexpressionisalsoseeninmonocytes,macrophages,endothelialcells(constitutivelyexpressed),fibroblasts,smoothmusclecells,kidneyepithelialcells,synovialcells,chondrocytes,ADIpocytes,alveolarepithelialcells,granulosacellsandglialcells.PTX3expressioncanbeaffectedbyseveralpathways.PTX3isalsolinkedtothecomplementsystem.ItbindstoC1q,complementfactorHandficolin-2andisthereforeinvolvedintheclassical,alternativeaswellasthelectinpathwayofcomplement.PTX3seemstohaveaimportantregulatingroleofcomplementmediatedimmuneresponses.PTX3actsasanacutephaseproteinandisapotentialMarkerforinfectious,inflammatoryandcardiovascularpathologies.PTX3mayplayaroleinvascularpathology,includingatherosclerosisandrestenosis,andhasbeenconsideredasamarkerofvasculardamage.Inhumans,PTXslevelsarecorrelatedwiththeriskofdevelopingofvascularevents.ItisexpectedthatPTX3haveacardiovascularprotectiveeffect.FurThermore,PTX3upregulationisobservedintheendotheliumfrompatientsaffectedbysystemicsclerosis,adiseasecharacterizedbyinsufficientangiogenesis.Thelatterseemstobemediatedviafibroblastgrowthfactor2(FGF2).Theanti-angiogenicaffectofPTX3,viaFGF2,hasalsopotentialtointerferewithtumorprogression.LikeCRPandSAP,PTX3bindsapoptoticcellsanddebris,andhasbeenassociatedwiththeresponsetotissuedamage.Thisrecognitionofapoptoticcellsissharedbyothercomponentsofinnateimmunity(e.g.collectins).PTX3expressioncanbeaffectedbyseveralpathways.PTX3isalsolinkedtothecomplementsystem.ItbindstoC1q,complementfactorHandficolin-2andisthereforeinvolvedintheclassical,alternativeaswellasthelectinpathwayofcomplement.PTX3seemstohaveaimportantregulatingroleofcomplementmediatedimmuneresponses.PTX3actsasanacutephaseproteinandisapotentialmarkerforinfectious,inflammatoryandcardiovascularpathologies.PTX3mayplayaroleinvascularpathology,includingatherosclerosisandrestenosis,andhasbeenconsideredasamarkerofvasculardamage.Inhumans,PTXslevelsarecorrelatedwiththeriskofdevelopingofvascularevents.ItisexpectedthatPTX3haveacardiovascularprotectiveeffect.Furthermore,PTX3upregulationisobservedintheendotheliumfrompatientsaffectedbysystemicsclerosis,adiseasecharacterizedbyinsufficientangiogenesis.Thelatterseemstobemediatedviafibroblastgrowthfactor2(FGF2).Theanti-angiogenicaffectofPTX3,viaFGF2,hasalsopotentialtointerferewithtumorprogression.LikeCRPandSAP,PTX3bindsapoptoticcellsanddebris,andhasbeenassociatedwiththeresponsetotissuedamage.Thisrecognitionofapoptoticcellsissharedbyothercomponentsofinnateimmunity(e.g.collectins).
Specifications:
| Catalognumber | HM1131BT |
|---|---|
| Producttype | Monoclonalantibodies |
| Quantity | 50µg |
| Formulation | 0.5ml(100μg/ml)0.2μmfilteredantibodysolutioninPBS,containing0.1%bovineserumalbumin and0.02%sodiumazide. |
| Conjugate | Biotin |
| Application | Flowcytometry,Frozensections,Functionalstudies,Immunoassays,Westernblot |
| ApplicationNotes | W:AreducedsampletreatmentandSDS-Pagewasused. |
| Use | Forflowcytometry,immunoassayandWesternblotting,dilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50.Forfunctionalstudies,invitrodilutionshavetobeoptimizedinuser’sexperimentalsetting. |
| Immunogen | RecombinantmousePTX3 |
| Isotype | MouseIgG1 |
| Species | Mouse |
| PositiveControl | Sectionofinflammedtissues. |
| NegativeControl | Sectionofnormaltissues. |
| StorageandstABIlity | Productshouldbestoredat4°C.Underrecommendedstorageconditions,productisstableforatleastoneyear.Theexactexpirydateisindicatedonthelabel. |
| Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandfederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultfromtheuseorderivationofthisproduct. |
| Disease | Cardiologyandmetabolism,Infectiousdiseases |
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。
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