Hycult Biotech/TREM-2, Mouse, mAb 6E9/HM1129/100 µg
商品编号：
HM1129
品牌：
hycultbiotech
市场价：
¥6432.00
美元价：
3859.20
产品分类：
单克隆抗体
公司分类：
monoclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Description:TREM-2,Mouse,mAb6E9
Themonoclonalantibody6E9recognizesmousemembrane-boundaswellassolubletriggeringreceptorexpressedonmyeloidcells-2(TREM-2).TREM-2isa26kDatransmembraneglycoproteinthatconsistsofasingleextracellularimmunoglobulin-likedomain,atransmembraneregionwithachargedlysineresidueandashortcytoplasmictail.ItassociateswithDNAX-activationprotein12(DAP12)forsignalingandfunction.TREM-2isexpressedonimmaturemonocyte-deriveddendriticcells.Afteractivationbymicrobialproductsortumornecrosisfactor(TNF)andTNF-relatedproteins,dendriticcellsdownregulatetheexpressionofTREM-2.TREM-2isalsoexpressedbyosteoclastsandmicroglia,whereitisinvolvedinbonemodelingandbrainfunction,respectively.AnotherroleofTREM-2mightbepromotingtheremovalofapoptoticcells,organicmatrixandmacromoleculesbymicroglia.DefectsinTREM-2areacauseofpolycysticlipomembranousosteodysplasiawithsclerosingleukoencephalopathy(PLOSL),alsocalledpreseniledementiawithbonecystsorNasu-Hakoladisease(NHD).TREM-2,likeTREM-1,canbecleavedonthemembranetoreleaseasolubleformofTREM-2(sTREM-2).ElevatedlevelsofsTREM-2inCSFofmultiplesclerosispatientshavebeendetected.Thiselevatedlevelmayinhibittheanti-inflammatoryfunctionofthemembrane-boundreceptorsuggestingsTREM-2tobeapossIBLetargetforfuturetherapies.
Specifications:
| Catalognumber | HM1129 |
|---|---|
| Producttype | Monoclonalantibodies |
| Quantity | 100µg |
| Formulation | 1ml(100μg/ml)0.2μmfilteredantibodysolutioninPBS,containing0.1%bovineserumalbuminand0.02%sodiumazide. |
| Application | Flowcytometry,Immunoassays,Immunoprecipitation |
| Use | Forflowcytometry,dilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50. |
| Immunogen | MouserecombinantTREM-2protein |
| Isotype | RatIgG2b |
| Species | Mouse |
| Alias | Triggeringreceptorexpressedonmonocytes2,TREM2 |
| References | Koga,Tetal;CostimulatorysignalsmediatedbytheITAMmotifcooperatewithRANKLforbonehomeostasis.Nature2004,428:758 |
| StorageandstABIlity | Productshouldbestoredat4°C.Underrecommendedstorageconditions,productisstableforoneyear. |
| Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandfederalrulesintheuseofthisproduct.HycultBiotechisnotresponsibleforanypatentinfringementsthatmightresultfromtheuseorderivationofthisproduct. |
| Disease | Neurologicaldisorders |
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。
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