Hycult Biotech/TLR2, Mouse, mAb mT2.4, FITC/HM1092F/100 µg
商品编号:
HM1092F
品牌:
hycultbiotech
市场价:
¥7752.00
美元价:
4651.20
产品分类:
单克隆抗体
公司分类:
monoclonal_antibody
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Description:TLR2,Mouse,mAbmT2.4,FITC
MonoclonalantibodymT2.4reactswithmouseToll-likereceptor2(TLR2,CD282).Toll-likereceptors(TLR)arehighlyconservedthroughoutevolutionandhavebeenimplicatedintheinnatedefensetomanypathogens.InDrosophilatollisrequiredfortheanti-fungalresponse,whiletherelated18-wheelerisinvolvedinantibacterialdefenses.Inmammals,TLRidentifiedastypeItransmembranesignalingreceptorswithpatternrecognitioncapABIlities,havebeenimplicatedintheinnatehostdefensetopathogens.TLR2hasbeenidentifiedasareceptorthatiscentraltotheinnateimmuneresponsetolipoproteinsofGram-negativebacteria,severalwholeGram-positivebacteria,aswellasareceptorforpeptidoglycanandlipoteichoicacidandotherbacterialcellmembraneproducts.AfunctionalinteractionbetweenTLR2andTLR6inthecellularresponsetovariousbacterialproductshasbeendiscovered.ThecurrentlyacceptedparADIgmregardsTLR2asanessentialreceptorformanyeubacterialcellwallcomponents,includinglipoproteinsandpeptidoglycan.Bacterialspeciesasdiverseasmycobacteria,spiRochetes,mycoplasma,Staphylococcusaureus,andStreptococcuspneumoniaehaveallbeenshowntomediatecellularactivationviaTLR2.ThemonoclonalantibodymT2.4inhibitsmurineTLR2-mediatedcellactivation.ItmasksthelipopeptidebindingsiteintherecombinantextracellulardomainofTLR2(TLR2ECD)anddoesnothinderthereceptorcomplexformation.TheantibodyreactswiththenativeTLR2proteinandnotwithdenaturedTLR2protein.FurThermoretheantibodystainsoverexpressed,aswellasendogenouscellsurface-andintracellularmouseTLR2.
Specifications:
Catalognumber | HM1092F |
---|---|
Producttype | Monoclonalantibodies |
Quantity | 100µg |
Formulation | 1ml(100μg/ml)0.2μmfilteredFITCconjugatedantibodysolutioninPBS,containing0.02%sodiumazideand1%bovineserumalbumin. |
Conjugate | FITC |
Application | Flowcytometry,Frozensections,Functionalstudies,Immunoassays,Paraffinsections |
Use | Forimmunohistologyandflowcytometrydilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50.ForneutralizationofBIOLOGicalactivityinvitrodilutionshavetobemadeaccordingtotheamountsofTLR2(CD282)tobeinactivated. |
Isotype | MouseIgG2b |
Species | Mouse |
References | Meng,Getal;MurineTLR2expressionanalysisandsystemicantagonismbyusageofspecificmonoclonalantibodies.ImmunologyLetters2005,98:200 |
Storageandstability | Productshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear. |
Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultwiththeuseoforderivationofthisproduct. |
Disease | Infectiousdiseases |
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登,从1994开始制造检测抗体和蛋白质,主要侧重与病理学诊断有关的全套产品研发,既有纯化的重组蛋白和多肽,也有单抗和多抗,是世界一流的先天免疫领域的研究试剂制造商。
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