4000-520-616
欢迎来到免疫在线!(蚂蚁淘生物旗下平台)  请登录 |  免费注册 |  询价篮
主营:主营:病理学诊断相关的抗体,蛋白质
咨询热线电话
4000-520-616
当前位置: 首页 > 产品中心 > monoclonal_antibody > Hycult BITECH/Properdin,人,单克隆抗体2.9 | Hycult BITECH/HM2282
商品详细Hycult BITECH/Properdin,人,单克隆抗体2.9 | Hycult BITECH/HM2282
Hycult BITECH/Properdin,人,单克隆抗体2.9 | Hycult BITECH/HM2282
Hycult BITECH/Properdin,人,单克隆抗体2.9 | Hycult BITECH/HM2282
商品编号: HM2282
品牌: hycultbiotech
市场价: ¥5620.00
美元价: 3372.00
产地: 美国(厂家直采)
公司:
产品分类: 单克隆抗体
公司分类: monoclonal_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
The monoclonal antibody 2.9 reacts with human properdin (factor P), which is a single-chain plasmaglycoprotein with an apparent molecular mass of 52-55 kDa, The protein domain structure ofproperdin consists of six thrombospondin repeat sequences between short N- and C-terminaldomains. In blood, properdin exists as a mixture of head-to-tail dimers, trimers and tetramers. Theprotein is expressed by a variety of leukocytes, including monocytes, T lymphocytes and neutrophils,but also by endothelial cells in which properdin synthesis is induced by certain stress factors.Properdin participates in the alternative pathway of complement activation together with C3 andfactors B, D, I and H by prolonging the half-life of the labile C3bBb, which is deposited on immunecomplexes or foreign surfaces. This permits amplification of C3bBb formation in competition withcatabolism of C3b by factor I, which uses factor H as a cofactor. The local amplification process leadsto the creation of the alternative pathway C5 convertase, C3bBb3b, and initiates the terminal pathwayof complement activation. As a consequence, properdin is consumed by binding to C3bBb, whichshows an order of preference of tetramers over trimers over dimers, which corresponds to thefunctional activity of the oligomeric forms. Deficiency or malfunction of the molecule may lead tosevere impairment of alternative pathway activation, depending on the precise nature of the defect.Three types of deficiencies have been described so far: type 1 (or I) is characterized by serum withvery low or absent properdin activity in hemolytic assays and <0.1 μg/ml="" immunoreactive="" protein;="" type="" 2="" (or="" ii)="" is="" characterized="" by="" low="" but="" detectable="" levels="" of="" immunoreactive="" protein="" (="">2 μg/ml) andimpairment of some, but not all functional test, and type 3 (or III) has normal levels of immunoreactivebut dysfunctional protein (5-25 μg/mL). Lower properdin levels were found in 70% of diabetic patientswhen compared to nondiabetic controls and is suggested by the authors that patients with lowexpression of properdin take preventive measures and early treatments against infection. Themonoclonal antibody 2.9 is suitable for functional studies as well as use in immunoassays.
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登,从1994开始制造检测抗体和蛋白质,主要侧重与病理学诊断有关的全套产品研发,既有纯化的重组蛋白和多肽,也有单抗和多抗,是世界一流的先天免疫领域的研究试剂制造商。