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当前位置: 首页 > 产品中心 > monoclonal_antibody > Hycult Biotech/DAF, Human, mAb, 1C6 | Hycult Biotech/HM2280
商品详细Hycult Biotech/DAF, Human, mAb, 1C6 | Hycult Biotech/HM2280
Hycult Biotech/DAF, Human, mAb, 1C6  | Hycult Biotech/HM2280
Hycult Biotech/DAF, Human, mAb, 1C6 | Hycult Biotech/HM2280
商品编号: HM2280
品牌: hycultbiotech
市场价: ¥6980.00
美元价: 4188.00
产地: 美国(厂家直采)
公司:
产品分类: 单克隆抗体
公司分类: monoclonal_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
The monoclonal antibody 1C6 recognizes human complement decay-accelerating factor (DAF), also designated as CD55. Cells express on their surface several proteins which protect against complement attack, namely complement receptor I (CR1), decay-accelerating factor (DAF), membrane cofactor protein (MCP) and CD59. CR1, DAF and MCP regulate the activation pathways of complement by either accelerating decay of the C3 and C5 convertase (CR1, DAF), or acting as cofactors for the serine protease factor I, which cleaves and irreversibly inactivates C3b (CR1, MCP).Human DAF (CD55) is a protein of 381 amino acids resulting in a ~ 60 kDa transmembrane protein that binds C3b and C4b to inhibit formation and half-life of the C3 convertases. It belongs to the receptors of complement activation (RCA) family. DAF is broadly distributed among cells in contact with plasma complment proteins, including both haematopoietic and non-haematopoietic cells. Although DAF does not have an essential role in controling hemolysis of erythrocytes, it has an important role in regulation of the deposition of C3 on nucleated cells.Together with other complement regulators DAF protects self cells from autologous complement-mediated injury. DAF cooperates with CD46 in circumventing autologous C3 deposition, while CD59 inhibits the pathway at the critical end-point. DAF is overexpressed in certain tumors thereby limiting the complement-dependent cytotoxiticy of therapeutic anticancer antibodies. Using DAF blocking antibodies targeted specifically at cancer cells in combination with immunotherapeutic monoclonal antibodies of cancer may improve the therapeutic effect in cancer patients.
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登,从1994开始制造检测抗体和蛋白质,主要侧重与病理学诊断有关的全套产品研发,既有纯化的重组蛋白和多肽,也有单抗和多抗,是世界一流的先天免疫领域的研究试剂制造商。