Hycult Biotech/TNF-α，人，单克隆抗体5N/HM2218-05/0.5 mg
商品编号：
HM2218-05
品牌：
hycultbiotech
市场价：
¥20832.00
美元价：
12499.20
产品分类：
单克隆抗体
公司分类：
monoclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Description:TNF-alpha,Human,mAb5N
Themonoclonalantibody5NreactswithTumorNecrosisFactoralpha(TNF-alpha).Tumornecrosisfactor-alpha(TNF-alpha),ahomotrimeric17KDprotein,isapotentmediatorofinflammatoryandmetabolicfunctions.TNF-alphawasoriginallydetectedasahighlycytotoxiccytokinefortumorcells,itcausestumornecrosisinvivoandshowscytolyticactivityagainsttumorcellsinvitro.FurtherTNF-alphahasbeenimpliedascentralmediatorinshockinducedbygramnegativemicro-organisms.ThecytokineTNF-alphaisfoundtobeacentralmediatorinmanyinflammatoryandimmunologicalprocesses:itcanbeinducedbyvariousproductsofmicro-organismsandbyvariouscytokinesbutitalsoinducesonitsturntheproductionofmanycytokines.SignaltransductionoccursviatwotypesofTNF-receptors,theTNF-receptorsIandII.Thereceptorsdifferstronglyintheirintra-cellularsignalingpathways.TheTNF-alphatrimerinteractswitheitherofthetwotypesofTNF-RleADIngtoreceptorcross-linking.Themonoclonalantibody5Ncross-reactsandcross-neutralizesallmonkeyspeciesTNF-alpha,exceptpig-tailmacaque.WithaffinityabouttwoordersloweritrecognizesbovineandcanineTNF-alpha.
Specifications:
| Catalognumber | HM2218-05 |
|---|---|
| Producttype | Monoclonalantibodies |
| Quantity | 0.5mg |
| Formulation | 1ml(100µg/ml)0.2µmfilteredantibodysolutioninPBS,containing0.1%bovineserumalbumin. |
| Application | Functionalstudies,Immunoassays |
| Use | ForneutralizationofBIOLOGicalactivityinvitrodilutionshavetobemadeaccordingtotheamountsofTNF-alphatobeinactivated.Theaffinityofthemonoclonalantibody5Nis5.7x10-10M.ThehomologousELISAisusefulforthedetectionofoligomerichumanTNF-alpha.ItdoesnotrecognizemonomericTNF-alpha. |
| Isotype | MouseIgG2a |
| Species | Human |
| Crossreactivity | Bovine-Yes,Canine-Yes,Monkey-Yes |
| Alias | TNF,TNF-SF2,DIF,Cachectin |
| References | 1.Petyovka,Netal;HomologousELISAfordetectionofoligomerichumanTNF:propertiesoftheassay.JImmunolMethods1995,186:161 2.Song,Xetal;Effectsof2differentanti-tumornecrosisfactor-alphaagentsinaprimatemodelofsubcutaneousformation.JInfectDis2002,185:204 |
| StorageandstABIlity | Productshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear. |
| Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandfederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultfromtheuseorderivationofthisproduct. |
| Disease | Autoimmunity,Gastroenterology |
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。
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