Hycult Biotech/DC-SIGN，人类，单克隆抗体DCN47.5/HM2209/100µg
商品编号：
HM2209
品牌：
hycultbiotech
市场价：
¥7820.00
美元价：
4692.00
产品分类：
单克隆抗体
公司分类：
monoclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Description:DC-SIGN,Human,mAbDCN47.5
ThemonoclonalantibodyDCN47.5reactswiththeC-typelectin,DC-SIGN(CD209),exclusivelyexpressedonhumandendriticcells(DC).DCarespecializedantigenpresentingcellsandbridgetheinnateandtheadaptiveimmunesystem.Theyprovidehighlevelsofcostimulationnecessaryforactivationofbothnaïveandantigen-experiencedT-cells.ImmatureDCarecapabletomigratetoinflammatorysites,captureantigenandprocessitinternallytoformMHC-peptidecomplexes.Followingantigenuptake,DCundergomaturationandmigratetolymphoidorganswheretheycanpresentMHC-peptidecomplexestorestingT-cellsanddriveT-cellproliferation.DuringdifferentiationandmaturationofDC,severalphenotypicsurfaceMarkersareexpressed:CD1a,CD4,CD11,CD40,CD86,andHLA-DR.ImmatureDCpredominantlyexpressCCR5whichenablesDCtomigratetoinflammatorysites,whereasmatureDCexpresshighlevelsofCXCR4,areceptorthatfacilitatesmigrationtolymphoidorgans.
DCalsoexpressDC-specific,ICAM-3grabbing,nonintegrin(DC-SIGN),a44kDaC-typelectinthatbindstotheHIV-1envelopeglycoproteingp120,ICAM-3onT-cellsandICAM-2onendothelialcells.HIVvirionsareabletoinfectcellsexpressingCD4andthechemokineco-receptorsCCR5orCXCR4andcanattachtoDC-SIGNtoextendvirionLifespan.Therefore,DCarecandidatesforHIV-1infection.DC-SIGN-ICAM-3bindingisintegrin-independentbutcalcium-dependentandantibodiesreactiveagainstDC-SIGNcanbeusedtostudyDC-SIGN-ICAM3binding.ThemonoclonalantibodyDCN47.5specificallyreactswiththeC-typelectinDC-SIGN(CD209)expressedonhumandendriticcellsandinhibitsbindingofDC-SIGNtoICAM-2onendothelialcells.
DCalsoexpressDC-specific,ICAM-3grabbing,nonintegrin(DC-SIGN),a44kDaC-typelectinthatbindstotheHIV-1envelopeglycoproteingp120,ICAM-3onT-cellsandICAM-2onendothelialcells.HIVvirionsareabletoinfectcellsexpressingCD4andthechemokineco-receptorsCCR5orCXCR4andcanattachtoDC-SIGNtoextendvirionLifespan.Therefore,DCarecandidatesforHIV-1infection.DC-SIGN-ICAM-3bindingisintegrin-independentbutcalcium-dependentandantibodiesreactiveagainstDC-SIGNcanbeusedtostudyDC-SIGN-ICAM3binding.ThemonoclonalantibodyDCN47.5specificallyreactswiththeC-typelectinDC-SIGN(CD209)expressedonhumandendriticcellsandinhibitsbindingofDC-SIGNtoICAM-2onendothelialcells.
Specifications:
| Catalognumber | HM2209 |
|---|---|
| Producttype | Monoclonalantibodies |
| Quantity | 100µg |
| Formulation | 1ml(100μg/ml)0.2μmfilteredproteinGpurifiedantibodysolutioninPBScontaining0.1%bovineserumalbumin. |
| Application | Flowcytometry,Functionalstudies |
| Use | Dilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50. |
| Immunogen | Humanmonocyte-deriveddendriticcells |
| Isotype | MouseIgG1 |
| Species | Human |
| Alias | CD209antigen,C-typelectindomainfamily4memberL,Dendriticcell-specificICAM-3-grabbingnon-integrin1 Genename:CD209 |
| PositiveControl | humanlymphnodesorPHAactivatedTcells |
| References | 1.Leeuwenberg,JFMetal;SlowreleaseofsolubleTNF-Receptorsbymonocytesinvitro.JImmunol1994,152:4036 2.Leeuwenberg,JFMetal;LipopolysaccharideLPS-mediatedsolubleTNF-ReceptorreleaseandTNF-Receptorexpressionbymonocytes;roleofCD14,LPSbindingproteinandbactericidal/permeABIlity-increasingprotein.JImmnol1994,152:50703.Marchetti,Letal;Tumornecrosisfactor(TNF)-mediatedneuroprotectionagainstglutamate-inducedexcitotoxicityisenhancedbyN-methyl-D-aspartatereceptoractivation.EssentialroleofaTNFreceptor2-mediatedphosphatidylinositol3-kinasedependentNF-kappaBpathway.JBiolChem2004,279:32869 |
| Storageandstability | Productshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear. |
| Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultwiththeuseorderivationofthisproduct. |
| Disease | Infectiousdiseases |
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。
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