Hycult Biotech/Ficolin-1, Human, mAb 7G1/HM2196/100 µg
商品编号：
HM2196
品牌：
hycultbiotech
市场价：
¥10320.00
美元价：
6192.00
产品分类：
单克隆抗体
公司分类：
monoclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Description:Ficolin-1,Human,mAb7G1
Themonoclonalantibody7G1recognizeshumanM-ficolin,alsoknownasficolin-1.Ficolinsareafamilyofpatternrecognitionmoleculescontainingbothacollagen-likedomainandafibrinogen-likedomainthatarecapableofactivatingthecomplementsystem,throughassociationwithMASPs,onthesurfaceofmicroorganisms.Inhuman,threeFicolinsareknown:M-Ficolin,L-Ficolin(Ficolin-2),andH-Ficolin(Ficolin-3).M-Ficolin,ismainlyexpressedby-monocytes,granulocytesand-lungcellsandispresentlocallyinareasofinflammation.However,itwasrecentlyalsofoundinserumsuggestingthatM-FicolinalsohasaroleinsystemicimmunitylikeL-andH-Ficolin.FunctionalanalysisofM-Ficolinhasdemonstratedthatit’sligandissialicacidpresentonbacteriasincebindingwasabolishedbypriortreatmentofthebacteriawithsialidase.FurThermore,itwasshownthatM-ficolinfacilitatestheuptakeofE.coli-byaleukemicmonocytelymphomacellline,suggestingthatitfunctionsasaphagocyticreceptoronthesurfaceofcirculatingmonocytes.LowcordbloodconcentrationofM-ficolinhasbeen-associatedwithhighernecrotizingenterocolitis-associatedfatalityandtwoidentifiedSNPsintheM-ficolingeneareassociatedwiththedevelopmentofrheumatoidarthritis.Themonoclonalantibody7G1issuitableforuseinimmunoassaysandwesternblotting.-
Specifications:
| Catalognumber | HM2196 |
|---|---|
| Producttype | Monoclonalantibodies |
| Quantity | 100µg |
| Formulation | 1ml(100µg/ml)0.2µmfilteredantibodysolutioninPBS,containing0.1%bovineserumalbuminand0.02%sodiumazide.- |
| Application | Flowcytometry,Immunoassays,Westernblot |
| Use | ForImmunoassaysandWesternblotting,dilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50.Forfunctionalstudies,invitrodilutionshavetobeoptimizedinuser"sexperimentalsetting. |
| Immunogen | FulllengthrecombinantM-Ficolin- |
| Isotype | MouseIgG1 |
| Species | Human |
| Alias | Ficolin-1,ficolin/P35-related |
| References | 1.Wittenborn,T.etal;CharacteristicsandBIOLOGicalvariationsofM-Ficolin,apatternrecognitionmolecule,inplasma.JInnateImmun2009,2:167 2.Schlappbach,L.etal;M-ficolinintheneonatalperiod:Associationswithneedformechanicalventilationandmortalityinprematureinfantswithnecrotisingenterocolitis.MolecularBiology2009,46:2597 |
| StorageandstABIlity | Productshouldbestoredat4°C.Underrecommendedstorageconditions,productisstableforatleastoneyear.Theexactexpirydateisindicatedonthelabel. |
| Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandfederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultfromtheuseorderivationofthisproduct. |
| Disease | Cardiologyandmetabolism,Infectiousdiseases |
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。
联络我们
