Hycult Biotech/C3aR, Human, mAb 17, FITC/HM2195F/100 µg
商品编号：
HM2195F
品牌：
hycultbiotech
市场价：
¥10320.00
美元价：
6192.00
产品分类：
单克隆抗体
公司分类：
monoclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Description:C3aR,Human,mAb17,FITC
Themonoclonalantibody17reactswiththehumanreceptorforC3a.Themonoclonalantibody17isintheliteraturealsoreferredtoasclonehC3aRZ8.
InthecourseofcomplementactivationtheC3areceptorfunctionsasthecellsurfacereceptorfortheanaphylatoxinC3a,theC-terminal77aminoacidcleavageproductofthealphachainofC3,butnotforC3a-desArg.AllcellularresponsestoC3aarespecificallymediatedbyinteractionswiththemembraneboundC3areceptor,aseventransmembraneGTP-binding-protein-coupledreceptorthatbelongstotherhodopsinsupergenefamily.The54kDaC3areceptoriswidelydistributedin,myeloidcells,peripheraltissuesandthecentralnervoussystem.ExpressionofC3aRhasbeendemonstratedonneutrophils,monocytes,eosinophils,astrocytes,neuronsandglialcellsandisincreasedininflammatoryconditions.NoC3aRexpressionwasdetectableonlymphocytesandontonsillarBcellsevenafterstimulation.
InthecourseofcomplementactivationtheC3areceptorfunctionsasthecellsurfacereceptorfortheanaphylatoxinC3a,theC-terminal77aminoacidcleavageproductofthealphachainofC3,butnotforC3a-desArg.AllcellularresponsestoC3aarespecificallymediatedbyinteractionswiththemembraneboundC3areceptor,aseventransmembraneGTP-binding-protein-coupledreceptorthatbelongstotherhodopsinsupergenefamily.The54kDaC3areceptoriswidelydistributedin,myeloidcells,peripheraltissuesandthecentralnervoussystem.ExpressionofC3aRhasbeendemonstratedonneutrophils,monocytes,eosinophils,astrocytes,neuronsandglialcellsandisincreasedininflammatoryconditions.NoC3aRexpressionwasdetectableonlymphocytesandontonsillarBcellsevenafterstimulation.
Specifications:
| Catalognumber | HM2195F |
|---|---|
| Producttype | Monoclonalantibodies |
| Quantity | 100µg |
| Formulation | 1ml(100µg/ml)0.2µmfilteredantibodysolutioninPBS,containing0.02%sodiumazideand1%bovineserumalbumin. |
| Conjugate | FITC |
| Application | Flowcytometry,Frozensections |
| Use | Forflowcytometryandimmunohistochemistrydilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50. |
| Isotype | MouseIgG2b |
| Species | Human |
| References | 1.Luhmann,Aetal;ImmunohistochemicalanalysisofhumanandratC3areceptorexpressionbytheuseofmonoclonalantibodies.MolImmunol2001,38:108 |
| StorageandstABIlity | Productshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear. |
| Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultwiththeuseoforderivationofthisproduct. |
| Disease | Infectiousdiseases,Nephrology |
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。
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