Hycult Biotech/MASP-2/MAp19, Human, mAb 6G12/HM2191/100 µg
商品编号：
HM2191
品牌：
hycultbiotech
市场价：
¥10320.00
美元价：
6192.00
产品分类：
单克隆抗体
公司分类：
monoclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Description:MASP-2/MAp19,Human,mAb6G12
Themonoclonalantibody6G12reactswithhumanMASP-2andhumanMAp19.MASP-2isatrypsin-likeserineproteaseandplaysanimportantroleintheinitiationoftheMBLcomplementactivationpathway.Threepathwaysofcomplementactivationhavebeenreported:theantibody-dependentclassicalpathway,theantibody-independentalternativepathwayandthelectinpathway.Activationofeachpathwayinvolvesformationofserineproteasecomplexes,whichresultsinactivationofthecentralcomplementcomponentC3.Inthelectinpathway,mannosebinding-lectin(MBL)-associatedserineproteases(MASPs)formcomplexeswithpolymericlectinmoleculeswhichareinvolvedinpatternrecognition.Uponbindingoftherecognitionmoleculestocarbohydratesonthesurfaceofmicroorganisms,MASPsareconvertedtotheiractiveformsandinitiatecomplementactivation.ThreetypesofhumanMASPhavebeenreported.MASP-1,MASP-2andMASP-3.Mannan-bindinglectin(MBL)andficolins,incomplexwithMBL-associatedserinproteases(MASPs),arecapableofactivationthecomplementsystem,thusmediatingthedestructionofinfectiousagents.MASP-2cleavesC4andC2andiscrucialfortheactivationofdownstreamcomplementcomponents.MAp19isanalternativesplicingproductoftheMASP-2gene.MAp19comprisesthefirsttwodomainsofMASP-2followedbyanextrasequenceoffouruniqueaminoacids(EQSL)atitsC-terminal.MASP-2andMAp19havebeenreportedtobindtoMBLinacalcium-dependentmanner.
Themonoclonalantibody6G12reactswithhighaffinitytotheN-terminalendofMASP-2andMap19.
Themonoclonalantibody6G12reactswithhighaffinitytotheN-terminalendofMASP-2andMap19.
Specifications:
| Catalognumber | HM2191 |
|---|---|
| Producttype | Monoclonalantibodies |
| Quantity | 100µg |
| Formulation | 1ml(100μg/ml)0.2μmfilteredproteinGpurifiedantibodysolutioninPBS,containing0.02%sodiumazideand0.1%bovineserumalbumin. |
| Application | Immunoassays,Westernblot |
| ApplicationNotes | IA:theantibodycanbeusedasdetectionantibody. W:Bothreducedandnon-reducedcanbeperformed.TheexpectedbandsizeforMASP-2isapproximately75kDaandforMap19approximately20kDa. |
| Use | Dilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50. |
| Immunogen | rMAp19(Ref.1) |
| Isotype | RatIgG1 |
| Species | Human |
| References | 1.Moller-Kristensen,Metal;Levelsofmannan-bindinglectin-associatedserineprotease-2inhealthyindividuals.JImmunol2003,282:159 2.Krarup,Aetal;L-ficolinIsaPatternRecognitionMoleculeSpecificforAcetylGroups*.JBC2004,46:47513 3.Ameye,Letal;M-ficolinlevelsareassociatedwiththeoccurrenceofsevereinfectionsinpatientswithhaematologicalcancerundergoingchemotherapy.ClinExpImm2011,167:303 4.Zacho,Retal;StudiesofthePatternRecognitionMoleculeH-ficolin.JBC2012,11:8071 5.DamgaardSandahl,Tetal;ThelectinpathwayofthecomplementsystemisdownregulatedinCrohn"sdiseasepatientswhorespondtoanti-TNF-αtherapy.JCrohnCol2013,8:521 6.Man-Kupisinska,Aetal;ANewLigand-BasedMethodforPurifyingActiveHumanPlasma-DerivedFicolin-3ComplexesSupportsthePhenomenonofCrosstalkbetweenPattern-RecognitionMoleculesandImmunoglobulins.PLoSONE2016,11:e0156691 |
| StorageandstABIlity | Productshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear. |
| Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultwiththeuseoforderivationofthisproduct. |
| Disease | Infectiousdiseases |
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。
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