Hycult Biotech/TCC, Human, mAb aE11/HM2167/100 µg
商品编号：
HM2167
品牌：
hycultbiotech
市场价：
¥9288.00
美元价：
5572.80
产品分类：
单克隆抗体
公司分类：
monoclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Description:TCC,Human,mAbaE11
MonoclonalantibodyaE11reactswithaC9neoantigenoftheterminalcomplementcomplex(TCC).ThethreedistinctactivationpathwaysofcomplementconvergewiththeformationofaC5convertase.ThecleavageofC5bythisconvertaseinitiatesthelyticorterminalpathway.Incontrasttotheactivationpathways,whichrequireenzymaticcleavageforactivation,theterminalpathwayreliesonconformationalchangesinducedbybinding.BindingofC6facilitatesbindingofC7whichalterstheconformationofthecomplex.AfterbindingofC8,avariablenumberofC9moleculesassociatewiththeC5b678complex,whichisalsotermed-theterminalcomplementcomplex(TCC).TheformationofTCCcauseslysisofcellsorcantriggeravarietyofcellularmetabolicpathwaysresultinginthesynthesisandreleaseofinflammatorymediators.TheTCCcontainsneoantigensthatareabsentfromtheindividualnativecomponents.-C9neoantigensarepresentbothinthemembrane-bound(MAC)andthefluid-phase(SC5b-9)complex.TCCispresentinnormalhumanplasmaandincreasedinpatientswithcomplementactivation.
Specifications:
| Catalognumber | HM2167 |
|---|---|
| Producttype | Monoclonalantibodies |
| Quantity | 100µg |
| Formulation | 1ml(100μg/ml)0.2μmfilteredproteinGpurifiedantibodysolutioninPBScontaining0.1%bovineserumalbumin.Theendotoxinconcentrationis<24EU/mg,determinedwithHIT302LALAssay. |
| Application | Flowcytometry,Frozensections,Functionalstudies,Immunoassays,Immunofluorescence,Paraffinsections |
| ApplicationNotes | FS:AntibodyaE11inhibitsplateletactivationbyantiphospholipidantibodyserum.(Ref.5). IF:Cryosectionsof10μmweredried,fixedinacetoneat4°Cfor10min,driedandblockedfor20minwithPBSA. |
| Use | Dilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50. |
| Isotype | MouseIgG2a |
| Species | Human |
| Crossreactivity | Horse-Yes,Pig-Yes |
| Alias | Terminalcomplementcomplex,MACcomplex,complementmembraneattackcomplex,sC5b-9complex. |
| PositiveControl | MucosafrompatientswithH.Pylori. |
| References | 1.Mollnes,Tetal;Quantificationoftheterminalcomplementcomplexinhumanplasmabyanenzyme-linkedimmunosorbentassaybasedonmonoclonalantibodiesagainstaneoantigenofthecomplex.ScandJImmunol1985,22:1972.Mollnes,Tetal;Monoclonalantibodiesrecognizinganeoantigenofpoly(C9)detectthehumanterminalcomplementcomplexintissueandplasma.ScandJImmunol1985,22:1833.Pettersen,Hetal;HumanalveolarmacrophagessynthesizeactivecomplementcomponentsC6,C7,andC8invitro.ScandJImmunol1987,25:5674.Berstad,Aetal;EpitheliumrelateddepositionofactivatedcomplementinHelicobacterpyloriassociatedgastritis.Gut1997,40:1965.Stewart,Metal.Antiphospholipidantibody-dependentC5b-9formation.BJH1997,96:4516.Meuwissen,Metal.ColocalisationofintraplauqCreactiveprotein,complement,oxidisedlowdensitylipoprotein,andmacrophagesinstableandunstableanginaandacutemyocardialinfarction.JClinPath2005,59:126 |
| StorageandstABIlity | Productshouldbestoredat4°C.Underrecommendedstorageconditions,productisstableforatleastoneyear.Theexactexpirydateisindicatedonthelabel. |
| Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandfederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultfromtheuseorderivationofthisproduct. |
| Disease | Infectiousdiseases,Nephrology |
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。
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