Hycult Biotech/TLR5, Human, mAb 19D759.2/HM2159/100 µg
商品编号：
HM2159
品牌：
hycultbiotech
市场价：
¥6432.00
美元价：
3859.20
产品分类：
单克隆抗体
公司分类：
monoclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Description:TLR5,Human,mAb19D759.2
Themonoclonalantibody19D759.2recognizesanintracellularepitopeinthecytoplasmicdomainofhumanTLR5.TLRsbelongtoafamilyofproteinsthatspecificallyrecognizesandsensesmicrobialproducts.Theyarehighlyconservedthroughoutevolutionandhavebeenimplicatedintheinnatedefensetomanypathogens.InDrosophilatollisrequiredfortheanti-fungalresponse,whiletherelated18-wheelerisinvolvedinantibacterialdefenses.Inmammals,TLRidentifiedastypeItransmembranesignalingreceptorswithpatternrecognitioncapABIlities.ThevariousTLRsexhibitdifferentpatternsofexpression.TLR5isupregulatedinresponsetoexposuretoflagellatedbacteriaortheTLR5agoNIST,flagellin.Gram-negativebacteriastimulatemonocyte/macrophagecellsinaTLR5specific,CD14-independentmanner.TheinnateimmunesystemrecognizesflagellatedbacterialpathogensthroughtheTLR5receptorsignalling.ItactsviaMYD88andTRAF6,leADIngtoNF-kappa-Bactivation,cytokinesecretionandtheinflammatoryresponse.GeneticvariationinTLR5isassociatedwithresistancetosystemiclupuserythematosustype1(SLEB1).
Specifications:
| Catalognumber | HM2159 |
|---|---|
| Producttype | Monoclonalantibodies |
| Quantity | 100µg |
| Formulation | 1ml(100µg/ml)0.2µmfilteredantibodysolutioninPBS,containing0.1%bovineserumalbuminand0.02%sodiumazide. |
| Application | Flowcytometry,Frozensections,Paraffinsections,Westernblot |
| Use | Forimmunohistology,immunofluorescence,flowcytometryandWesternblotting,dilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50. |
| Immunogen | SyntheticpeptidecorrespondingtoaportionofhumanTLR5betweenaminoacid700-800conjugatedtoKLH |
| Isotype | MouseIgG2a |
| Species | Human |
| Alias | Toll-likereceptor5,TollInterleukin-1receptor-likeprotein3 |
| References | 1.Miller,Letal;TGF-alpharegulatesTLRexpressionandfunctiononepidermalkeratinocytes.JImmunol2005,174:6137 2.Burgener,Ietal;AntibodiesspecificforhumanormurineToll-likereceptorsdetectcanineleukocytesbyflowcytometry.VetImmunolImmunopathol2008,124:184 3.Deng,Jetal;Toll-likereceptors4and5inducedistincttypesofvasculitis.CircRes2009,104:488 4.Ritter,Metal;CharacterizationofToll-likereceptorsinprimarylungepithelialcells:strongimpactoftheTLR3ligandpoly(I:C)ontheregulationofToll-likereceptors,adapterproteinsandinflammatoryresponse.JofInflammation2005,2:16 |
| Storageandstability | Productshouldbestoredat4°C.Underrecommendedstorageconditions,productisstableforoneyear. |
| Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandfederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultfromtheuseorderivationofthisproduct. |
| Disease | Infectiousdiseases |
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。
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