Hycult Biotech/Protein C，人，单克隆抗体PC107/HM2151/100µg
商品编号：
HM2151
品牌：
hycultbiotech
市场价：
¥8736.00
美元价：
5241.60
产品分类：
单克隆抗体
公司分类：
monoclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Description:ProteinC,Human,mAbPC107
MonoclonalantibodyPC107isspecificforactivatedProteinC(APC).ProteinC(PC)isanimportantregulatorofthebloodcoagulationsystem.TheanticoagulantPCisconvertedtoactivatedproteinC(APC)bythethrombomodulin(TM)-thrombincomplexonthephospholipidsurfaceofendothelialcells,monocytes,andplatelets.ThisprocessisenhancedinthepresenceoftheendothelialproteinCreceptor(EPCR).Inadditiontoitsregulatoryfunctioninthebloodcoagulationsystem,studiesindicateimportantrolesforAPCininflammatoryprocesses.TheadmiNISTrationofAPCpreventslethaleffectsofEscherichiacoli-associatedsepsisinexperimentalanimalmodelsandappearseffectiveforthetreatmentofpatientswithmeningococcemiaoracquiredPCdeficiency.TreatmentwithAPCimprovestheclinicaloutcomeofpatientswithsepsis.Theanti-inflammatoryactivityofAPCdependsonitsABIlitytosuppressthesecretionofcytokinesastumornecrosisfactor-alphabyinflammatorycells,theactivationandextravasationofleukocytesandtheexpressionandfunctionofadhesionmolecules.APCmayalsosuppresstheexpressionofgrowthfactorsandmembersofnuclearfactor-kB(NF-kB)familyoftranscriptionfactors.ThemonoclonalantibodyPC107isspecificforactivatedhumanproteinC(APC)anditlacksreactivityforProteinC.ThemonoclonalantibodyrecognizesthelightchainoftheAPCmolecule.
Specifications:
| Catalognumber | HM2151 |
|---|---|
| Producttype | Monoclonalantibodies |
| Quantity | 100µg |
| Formulation | 1ml(100µg/ml)0.2µmfilteredantibodysolutioninPBS,containing0.02%sodiumazideand0.1%bovineserumalbumin. |
| Application | Immunoassays,Westernblot |
| Use | ForWesternblottingdilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50. |
| Isotype | RatIgG1 |
| Species | Human |
| Storageandstability | Productshouldbestoredat4°C.Underrecommendedstorageconditions,productisstableforoneyear. |
| Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultwiththeuseoforderivationofthisproduct. |
| Disease | Cardiologyandmetabolism |
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。
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