Hycult Biotech/C5aR, Human, mAb W17/1/HM2095/100 µg
商品编号：
HM2095
品牌：
hycultbiotech
市场价：
¥8232.00
美元价：
4939.20
产品分类：
单克隆抗体
公司分类：
monoclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Description: C5aR, Human, mAb W17/1
The human anaphylatoxin C5a is a 74-residu glycopolypeptide which is generated by proteolytic cleavage of the complement factor C5 in the course of complement activation. A variety of biological effects evoked by C5a could be demonstrated, rendering this molecule an important mediator of inflammation, with granulocytes and macrophages as the main target cells. All cellular responses to C5a are specifically mediated by interactions with the membrane bound C5a receptor, a seven transmembrane GTP-binding-protein-coupled receptor that belongs to the rhodopsin supergene family. The C5a receptor is approximately 45 kDa.
Specifications:
| Catalog number | HM2095 |
|---|---|
| Product type | Monoclonal antibodies |
| Quantity | 100 µg |
| Formulation | 1 ml (100 µg/ml) 0.2 µm filtered antibody solution in PBS, containing 0.1% bovine serum albumin and 0.02 % sodium azide. |
| Application | Flow cytometry, Frozen sections, Paraffin sections |
| Use | For immunohistology and flow cytometry, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10. |
| Isotype | Mouse IgG1 |
| Species | Human |
| References | 1. Opperman, M et al; Probing the human receptor for C5a anaphylatoxin with side-directed antibodies. J Immunol 1993, 151: 3785 2. Opperman, M et al; Antibodies from the myeloid panel that react with the C5a receptor and antagonize C5a biological activity. Schlossman, S.F. (ed.) Leucocyte typing V.O.U.P.: 955-956 3. Werfel, T et al; Binding of anti-C5a receptor (C5aR) antibodies to cells of clinically normal human skin. Schlossman, S.F. (ed.) Leucocyte typing V.O.U.P.: 957-959 4. Opperman, M et al; Plasma clearance of human C5a anaphylatoxin by binding to leucocytes C5a receptors. Immunol 1994, 82: 516 |
| Storage and stability | Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year. |
| Precautions | For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and Federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result with the use of or derivation of this product. |
| Disease | Infectious diseases, Nephrology |
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。
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