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当前位置: 首页 > 产品中心 > monoclonal_antibody > Hycult Biotech/Alpha-V/Beta-3 Integrin, Human, mAb BV3, FITC/HM2034F/100 µg
商品详细Hycult Biotech/Alpha-V/Beta-3 Integrin, Human, mAb BV3, FITC/HM2034F/100 µg
Hycult Biotech/Alpha-V/Beta-3 Integrin, Human, mAb BV3, FITC/HM2034F/100 µg
Hycult Biotech/Alpha-V/Beta-3 Integrin, Human, mAb BV3, FITC/HM2034F/100 µg
商品编号: HM2034F
品牌: hycultbiotech
市场价: ¥10320.00
美元价: 6192.00
产地: 美国(厂家直采)
公司:
产品分类: 单克隆抗体
公司分类: monoclonal_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Description:Alpha-V/Beta-3Integrin,Human,mAbBV3,FITC

ThemonoclonalantibodyBV3recognizeshumanalpha-V/beta-3integrinpresentonhumancells.Integrinsareasuperfamilyofαβheterodimericcell-surfaceadhesionreceptorsfoundinmanyspecies.Theyareexpressedonavarietyofcellsandmediatenumerousphysiologicalprocesses,includinginflammation,migration,adhesionandproliferation.Theβ3familyconsistof2members:αIIbβ3andαvβ3,whichmediatecell-cellandcell-ECMinteractionsandareimportantforcellularmigration,regulationofgeneexpression,cellsurvival,adhesionanddifferentiation.Allprocesseswhichareinvolvedintissuedevelopment,angiogenesisandthrombosis.Eachsubunitconsistofanextracellulardomain,asingletransmembranesegmentandacytoplasmictail.TheyconnecttotheactinCytoskeletonviaadaptorproteinsthatbindtheircytoplasmictails.Cellmatrixadhesionsalsoactassignalingunitsbytheircapacitytoorganizetheactincytoskeletonandtoaccumulatevarioussignalingintermediates.Integrinαvβ3wasoriginallyidentifiedasthevitronectinreceptor.Nevertheless,otherligandsincludefibrinogen,fibronectin,laminin,thrombospondin,VonWillebrandfactor,tenascin,osteopontinandseveralformsofcollagen.Theinteractionsofintegrinαvβ3tothoseligandsismediatedbytheRGD(Arg-Gly-Asp)sequencemotifpresentintheseproteins.Deregulationofβ3integrinsisinvolvedine.g.autoimmunediseases,cardiovasculardisorders,transplantrejectionandtumOrigenesis.Incontributiontothelatter,integrinαvβ3contributebysupportinggrowthofsmall(tumor)bloodvesselstherebypotentiatingthemetastaticpotential.Overexpressionofintegrinαvβ3hasbeendemonstratedinvarioustumorsandactivatedendothelium.

Specifications:

CatalognumberHM2034F
ProducttypeMonoclonalantibodies
Quantity100µg
Formulation1ml(100µg/ml)FITCconjugatedantibodysolutioninPBS,containing1%bovineserumalbuminand0.02%sodiumazide
ConjugateFITC
ApplicationParaffinsections
ApplicationNotesFC:AntibodyBV3stainstheextracellulardomainofintegrinαvβ3.Thecellswerefixedin4%paraformaldehydebeforebeforeanalysis.Negativecontroltheprimaryantibodywasomitted.(Ref.2)
IHC:TissuesectionsfixedinHistochoiceandblockedwith5%BSA.(Ref.1).
UseForflowcytometryandimmunohistochemistrydilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50.
IsotypeMouseIgG1
SpeciesHuman
CrossreactivityHuman-Yes
AliasVitronectinreceptor,integrinalpha-v/beta-3,cd51/cd62
PositiveControlHUVECcells
References1.Newton,Setal.;Electroconvulsiveseizureincreasesadulthippocampalangiogenesisinrats.EurJneurosc.2006,24:819-828
2.Merkel,Oetal.;Integrinαvβ3targetedgenedeliveryusingRGDpeptidomimeticconjugateswithcopolymersofPRGylatedpoly(ethyleneimine).Bioconjchem..2009,20:1270-1280
3.Dare,Eetal.;Fibrinsealantsfromfresh/frozenplasmaasscaffoldsforinvitroarticularcartilageregeneration.Tissueengineering,2009,15:2285
StorageandstABIlityProductshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforatleastoneyear.Theexactexpirydateisindicatedonthelabel.
PrecautionsForresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandfederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultfromtheuseorderivationofthisproduct.
DiseaseAutoimmunity,Cardiologyandmetabolism
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登,从1994开始制造检测抗体和蛋白质,主要侧重与病理学诊断有关的全套产品研发,既有纯化的重组蛋白和多肽,也有单抗和多抗,是世界一流的先天免疫领域的研究试剂制造商。