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Hycult Biotech/Alpha-V/Beta-3 Integrin, Human, mAb BV3, FITC/HM2034F/100 µg
Hycult Biotech/Alpha-V/Beta-3 Integrin, Human, mAb BV3, FITC/HM2034F/100 µg
商品编号:
HM2034F
品牌:
hycultbiotech
市场价:
¥10320.00
美元价:
6192.00
产品分类:
单克隆抗体
公司分类:
monoclonal_antibody
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Description:Alpha-V/Beta-3Integrin,Human,mAbBV3,FITC
ThemonoclonalantibodyBV3recognizeshumanalpha-V/beta-3integrinpresentonhumancells.Integrinsareasuperfamilyofαβheterodimericcell-surfaceadhesionreceptorsfoundinmanyspecies.Theyareexpressedonavarietyofcellsandmediatenumerousphysiologicalprocesses,includinginflammation,migration,adhesionandproliferation.Theβ3familyconsistof2members:αIIbβ3andαvβ3,whichmediatecell-cellandcell-ECMinteractionsandareimportantforcellularmigration,regulationofgeneexpression,cellsurvival,adhesionanddifferentiation.Allprocesseswhichareinvolvedintissuedevelopment,angiogenesisandthrombosis.Eachsubunitconsistofanextracellulardomain,asingletransmembranesegmentandacytoplasmictail.TheyconnecttotheactinCytoskeletonviaadaptorproteinsthatbindtheircytoplasmictails.Cellmatrixadhesionsalsoactassignalingunitsbytheircapacitytoorganizetheactincytoskeletonandtoaccumulatevarioussignalingintermediates.Integrinαvβ3wasoriginallyidentifiedasthevitronectinreceptor.Nevertheless,otherligandsincludefibrinogen,fibronectin,laminin,thrombospondin,VonWillebrandfactor,tenascin,osteopontinandseveralformsofcollagen.Theinteractionsofintegrinαvβ3tothoseligandsismediatedbytheRGD(Arg-Gly-Asp)sequencemotifpresentintheseproteins.Deregulationofβ3integrinsisinvolvedine.g.autoimmunediseases,cardiovasculardisorders,transplantrejectionandtumOrigenesis.Incontributiontothelatter,integrinαvβ3contributebysupportinggrowthofsmall(tumor)bloodvesselstherebypotentiatingthemetastaticpotential.Overexpressionofintegrinαvβ3hasbeendemonstratedinvarioustumorsandactivatedendothelium.
Specifications:
Catalognumber | HM2034F |
---|---|
Producttype | Monoclonalantibodies |
Quantity | 100µg |
Formulation | 1ml(100µg/ml)FITCconjugatedantibodysolutioninPBS,containing1%bovineserumalbuminand0.02%sodiumazide |
Conjugate | FITC |
Application | Paraffinsections |
ApplicationNotes | FC:AntibodyBV3stainstheextracellulardomainofintegrinαvβ3.Thecellswerefixedin4%paraformaldehydebeforebeforeanalysis.Negativecontroltheprimaryantibodywasomitted.(Ref.2) IHC:TissuesectionsfixedinHistochoiceandblockedwith5%BSA.(Ref.1). |
Use | Forflowcytometryandimmunohistochemistrydilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50. |
Isotype | MouseIgG1 |
Species | Human |
Crossreactivity | Human-Yes |
Alias | Vitronectinreceptor,integrinalpha-v/beta-3,cd51/cd62 |
PositiveControl | HUVECcells |
References | 1.Newton,Setal.;Electroconvulsiveseizureincreasesadulthippocampalangiogenesisinrats.EurJneurosc.2006,24:819-828 2.Merkel,Oetal.;Integrinαvβ3targetedgenedeliveryusingRGDpeptidomimeticconjugateswithcopolymersofPRGylatedpoly(ethyleneimine).Bioconjchem..2009,20:1270-1280 3.Dare,Eetal.;Fibrinsealantsfromfresh/frozenplasmaasscaffoldsforinvitroarticularcartilageregeneration.Tissueengineering,2009,15:2285 |
StorageandstABIlity | Productshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforatleastoneyear.Theexactexpirydateisindicatedonthelabel. |
Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandfederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultfromtheuseorderivationofthisproduct. |
Disease | Autoimmunity,Cardiologyandmetabolism |
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登,从1994开始制造检测抗体和蛋白质,主要侧重与病理学诊断有关的全套产品研发,既有纯化的重组蛋白和多肽,也有单抗和多抗,是世界一流的先天免疫领域的研究试剂制造商。
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