Hycult Biotech/H-FABP, Human, mAb 67D3/HM2018/100 µg
商品编号：
HM2018
品牌：
hycultbiotech
市场价：
¥7200.00
美元价：
4320.00
产品分类：
单克隆抗体
公司分类：
monoclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Description:H-FABP,Human,mAb67D3
Themonoclonalantibody67D3recognizeshumanheart-typefattyacid-bindingprotein(H-FABP)ofbothnaturalandrecombinantorigin.TheH-FABPproteinisderivedfromthehumanFABP3gene.FABPsaresmallintracellularproteins(~13-14kDa)withahighdegreeoftissuespecificitythatbindlongchainfattyacids.Theyareabundantlypresentinvariouscelltypesandplayanimportantroleintheintracellularutilizationoffattyacids,transportandmetabolism.ThereareatleastninedistincttypesofFABP,eachshowingaspecificpatternoftissueexpression.Duetoitssmallsize,FABPleaksrapidlyoutofischemicallydamagednecroticcellsleADIngtoariseinserumlevels.Ischemicallydamagedtissuesarecharacterizedhistologicallybyabsence(orlowpresence)ofFABPfacilitatingrecognitionofsuchareas.H-FABPislocalizedintheheart,skeletalandsmoothmuscle,mammaryepithelialcells,aorta,distaltubulesofthekidney,lung,brain,placenta,andovary.FurThermore,thisantibodyisusefulforthepurificationofH-FABP.
Specifications:
| Catalognumber | HM2018 |
|---|---|
| Producttype | Monoclonalantibodies |
| Quantity | 100µg |
| Formulation | 1ml(100μg/ml)0.2μmproteinGpurifiedantibodysolutioninPBS,containing0.1%bovineserumalbuminand0.02%sodiumazide. |
| Application | Frozensections,Immunoassays,Immunoprecipitation,Westernblot |
| ApplicationNotes | IP:Biotinylated67D3wasimmobilizedonstreptavidinbeadsandaddedtoserumtoimmunoprecipitateH-FABP(Ref.3). W:Reducedsampletreatment.Thebandsizeis~15kDa(Ref.2). F:PermeABIlizationwasdoneincoldacetonewith0.5%hydrogenperoxidasefor10min,afterdryingandwashing,antibodieswereincubatedfor30minutes. |
| Use | Dilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50. |
| Immunogen | PurifiedHumanH-FABP |
| Isotype | MouseIgG1 |
| Species | Human |
| Crossreactivity | Mouse-Yes,Rat-Yes |
| Alias | Heart-typefattyacid-bindingprotein,Fattyacid-bindingprotein3,FABP3,Musclefattyacid-bindingprotein,Mammary-derivedgrowthinhibitor Genename:FABP3,FABP11,MDGI |
| PositiveControl | Heartcells,recombinanthumanH-FABP |
| NegativeControl | Tonsiltissue |
| References | 1.Roos,Wetal;Monoclonalantibodiestohumanheartfattyacid-bindingprotein.JImmunolMeth1995,183:149 2.Pelsers,Metal;Brain-andheart-typefattyacid-bindingproteinsinthebrain:tissuedistributionandclinicalutility.ClinChem2004,50:1568 3.Zhen,Eetal;QuantificationofheartfattyacidbindingproteinasabioMarkerfordrug-inducedcardiacandmusculoskeletalnecrosis.ProteomicsClinAppl2007,1:661 |
| Storageandstability | Productshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear. |
| Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandfederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultwiththeuseorderivationofthisproduct. |
| Disease | Cardiologyandmetabolism,Neurologicaldisorders |
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。
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