4000-520-616
欢迎来到免疫在线!(蚂蚁淘生物旗下平台)  请登录 |  免费注册 |  询价篮
主营:主营:病理学诊断相关的抗体,蛋白质
咨询热线电话
4000-520-616
当前位置: 首页 > 产品中心 > peptides > 海科生物技术/PAPC |海科生物技术/HC4043
商品详细海科生物技术/PAPC |海科生物技术/HC4043
海科生物技术/PAPC |海科生物技术/HC4043
海科生物技术/PAPC |海科生物技术/HC4043
商品编号: HC4043
品牌: hycultbiotech
市场价: ¥6340.00
美元价: 3804.00
产地: 美国(厂家直采)
公司:
产品分类: 多肽
公司分类: peptides
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
1-palmitoyl-2-arachidonoyl-sn-phosphatidylcholine (PAPC), is a naturally occuring phospholipid containing polyunsaturated arachidonic acid, which is a common lipid in mammalian cell membranes and lipoproteins. PAPC can be used as an unoxidized control in experiments utilizing oxidized PAPC (OxPAPC; cat. # HC4035/HC4036). OxPAPC, is a prototypic biologically active oxidized phospholipid first isolated from LDL minimally modified by oxidation (MM-LDL). OxPAPC is an active principle of MM-LDL and mimicks several pro- and anti-inflammatory effects induced by oxidized lipoproteins.Oxidation of PAPC generates two groups of oxidized phospholipids containing either fragmented or oxygenated sn-2 residues. The best-characterized fragmented species contain a five-carbon sn-2 residue bearing omega-aldehyde or omega-carboxyl groups. Oxygenation of arachidonic acid residue produces phospholipids containing esterified isoprostanes. Both fragmented and oxygenated species can regulate immune reactions.Pro-inflammatory effects of OxPAPC induce stimulation of endothelial cells to bind monocytes and induction of tissue clotting factor, IL-8, MCP-1, G-CSF and other mediators of atherothrombosis. Anti-inflammatory effects of OxPAPC are mediated by induction of protective enzymes such as heme oxygenase-1 and suppression of innate immune responses to bacterial lipopolysaccharide (LPS) due to inhibition of LPS recognition by LPS-binding protein (LBP) and CD14. OxPAPC is active in vivo and was shown to protect mice from lethal endotoxin shock.Biological activities of OxPAPC are mediated by a variety of signal transduction mechanisms, including elevation of cAMP and Ca2+ levels, activation of MAP kinases, PI-3-kinase and small GTPases Rac-1 and Cdc42. OxPAPC-induced protein synthesis is mediated by transcription factors such as Egr-1, NFAT, CREB, PPAR-alpha, PPAR-gamma, but does not involve NFkB-dependent transcription.
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登,从1994开始制造检测抗体和蛋白质,主要侧重与病理学诊断有关的全套产品研发,既有纯化的重组蛋白和多肽,也有单抗和多抗,是世界一流的先天免疫领域的研究试剂制造商。