Hycult Biotech/C4d, Rat, pAb/HP8034/100 µg
商品编号：
HP8034
品牌：
hycultbiotech
市场价：
¥7752.00
美元价：
4651.20
产品分类：
多克隆抗体
公司分类：
Polyclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Description:C4d,Rat,pAb
ThepolyclonalantibodyrecognizesratC4d.ComplementfactorC4(MW41kDa),formerlyknownasGgprotein,consistsofanalpha-,beta-andgamma-chain.Theclassicalpathwayofcomplementandthemannosebindinglectin(MBL)activationpathwayconvergeatC4.Activated,MASP-1andMASP-2cleaveC4resultingintheformationofC4aandC4b.ThelattercanbecleavedbyfactorIresultinginC4candC4d,inwhichstepallfunctionalsitesarelost.TheC4dactivationfragmentofC4isanexcellentMarkerforclassicalcomplementpathwayandMBLpathwayactivation.ThethioesterformedbetweenthesidechainsofCys1010andGln1013withintheC4dregionoftheα-chainmediatescovalentattachmenttothetargetsurfacebearingactivatedformsofC1sorMASP.FurThermore,C4dishighlyhomologoustoC3dwithover35%sharedaminoacidsequence.Inanumberofdiseasessuchasrheumatoidarthritis(RA),hereditaryangioedema(HAE),systemiclupuserythematosus(SLE)andchronicurticariawithhypercomplementemialevelsofC4daresignificantlyelevatedinserumorplasma.C4dlevelsmayalsobeelevatedinplasmafrompatientswithavarietyofhumoralautoimmunediseasesinwhichcomplementactivationisknowntooccur.DepositionofC4dinperitubularcapillarieshasbeenshowntobeasensitivemarkerforantibody-mediated(humoral)rejectioninrenaltransplantbiopsies.
Specifications:
| Catalognumber | HP8034 |
|---|---|
| Producttype | Polyclonalantibodies |
| Quantity | 100µg |
| Formulation | 1ml(100µg/ml)0.2µmfilteredantibodysolutioninPBS,containing0.1%bovineserumalbuminand0.02%sodiumazide. |
| Application | Flowcytometry,Frozensections,Paraffinsections,Westernblot |
| Use | Forimmunohistochemistry,flowcytometryandWesternblotting,dilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50. |
| Immunogen | Asynthesized14-merpeptide(STPAPRNPSEPVPQ)correspondingtoaminoacids1223-1236ofratC4,conjugatedtokeyholelimpethemocyaninattheC-terminalpart(forthisacysteinewasadded) |
| Isotype | RabbitIg |
| Species | Rat |
| References | 1.Minami,Ketal;C4ddepositionandclearanceincardiactransplantscorrelateswithalloantibodylevelsandrejectioninrats.AmJTransplant2006,6:923 2.Qian,Zetal;Antibodyandcomplementmediatedinjuryintransplantsfollowingsensitizationbyallogeneicbloodtransfusion.Transplant2006,82:857 3.Asano,H,etal;Treatmentwithriboflavinandultravioletlightpreventsalloimmunizationtoplatelettransfusionsandcardiactransplants.Transplant2007,84:1174 4.Murata,K,etal;C4ddepositionandcellularinfiltratesasmarkersofacuterejectioninratmodelsoforthotopiclungtransplantation.Transplant2008,86:123 |
| StorageandstABIlity | Productshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear. |
| Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandfederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultfromtheuseorderivationofthisproduct. |
| Disease | Infectiousdiseases,Nephrology |
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。
联络我们
