Hycult Biotech/C5L2, Rat, pAb/HP8018/100 µg
商品编号:
HP8018
品牌:
hycultbiotech
市场价:
¥7752.00
美元价:
4651.20
产品分类:
多克隆抗体
公司分类:
Polyclonal_antibody
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Description:C5L2,Rat,pAb
ThepolyclonalantibodyreactswithratC5L2.TheorphanreceptorC5L2isaseventransmembranereceptorwith40%aminoacidsequenceidentitytotheC5areceptor,CD88.Expressionhasbeenfoundongranulocytesandimmaturedendriticcells.IncontrasttoCD88,C5L2isuncoupledfromGproteinsduetoananaminoacidreplacementofargininebyleucineinthesocalledDRYregionattheendofthethirdintracellulartransmembranedomain.FollowingC5abinding,C5L2seemsneithertoinduceclassicalsignallingnortocauseBIOLOGicalresponses.WhenC5L2wastransfectedintoseveralcelltypes,C5afailedtoinducechemotaxis,degranulation,orinteracellularcalciummobilization.ThehighaffinfityofC5L2forC5aanditsmetabolite,C5adesArgandalowaffinityforC3aandC3adesArgsuggestthatthisreceptorisascavengerofcomplementfragmentsinvolvedinthedefenceagainsttheharmfulsideeffectsofcomplementactivation.C5L2expressiononhumanneutrophilsisknowntobedecreasedinsepsis;lossofexpressionmaybeaprognosticindicatorinthisconditionassurvivorsofsepsistendtohavehigherC5L2levels.
Specifications:
Catalognumber | HP8018 |
---|---|
Producttype | Polyclonalantibodies |
Quantity | 100µg |
Formulation | 1ml(100µg/ml)0.2 µmfilteredantibodysolutioninPBS,containing0.1%bovineserumalbumin. |
Application | Flowcytometry,Functionalstudies |
Use | Forflowcytometrydilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50. |
Isotype | RabbitIg |
Species | Rat |
References | 1.Cain,Setal;TheorphanreceptorC5L2hashighaffinitybindingsitesforcomplementfragmentsC5aandC5ades-Arg74.JBiolChem2002,277:7165 2.Kalant,Detal;Thechemoattractantreceptor-likeproteinC5L2bindstheC3ades-Arg77/acylation-stimulatingprotein.JBiolChem2003,278:11123 3.Huber-Lang,Metal;Changesinthenovelorphan,C5areceptor(C5L2),duringexperimentalsepsisandsepsisinhumans.JImmunol2005,174:1104 |
StorageandstABIlity | Productshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear. |
Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultwiththeuseoforderivationofthisproduct. |
Disease | Infectiousdiseases,Nephrology |
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登,从1994开始制造检测抗体和蛋白质,主要侧重与病理学诊断有关的全套产品研发,既有纯化的重组蛋白和多肽,也有单抗和多抗,是世界一流的先天免疫领域的研究试剂制造商。
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