Hycult Biotech/TNF-RI, Mouse, pAb/HP8002/100 µg
商品编号：
HP8002
品牌：
hycultbiotech
市场价：
¥9048.00
美元价：
5428.80
产品分类：
多克隆抗体
公司分类：
Polyclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Description:TNF-RI,Mouse,pAb
ThepolyclonalantibodyrecognizestheextracellularpartofthemouseTumorNecrosisFactorReceptortype1(TNF-RI)ofthemembrane-boundaswellasthesolublereceptor.TNF-RI(~55-60kDa)ispresentonmostcelltypesandisconsideredtoplayaprominentroleincellstimulationbyTNF-alpha.TNF-alphaactivatesinflammatoryresponses,inducesapoptosis,regulatescellularproliferation,andmayevenpromotecancerprogression.TheeffectsofTNF-alphaaremediatedbyTNF-RIandTNF-RII,whichhavebothdistinctandoverlappingdownstreamsignalingcascades.InductionofcytotoxicityandotherfunctionsaremediatedlargelyviaTNF-RI.TNF-RIisequallywellactivatedbyboththe17kDasolubleand26kDamembrane-boundform,whereasTNF-RIIisefficientlyactivatedonlybythemembraneboundformofTNF-alpha.TNF-RIsignalingisinitiatedwhentrimericTNF-alphabindsTNF-RIreceptors.SubsequentTNF-RItrimerizationpromotestherecruitmentofaproximalsignalingcomplexcomposedofTNFReceptorAssociatedproteinwithaDeathDomain(TRADD),ReceptorInteractingProtein(RIP),cellularInhibitorofApoptosisProtein1(cIAP1),TNFReceptorAssociatedFactor2(TRAF2),andlikelyTRAF5.StudieswithTNF-RI-deficientmiceindicatethatTNF-RImediatesmostoftheproliferation,pro-inflammatory,andapoptosis-activatingpathways.
Specifications:
| Catalognumber | HP8002 |
|---|---|
| Producttype | Polyclonalantibodies |
| Quantity | 100µg |
| Formulation | 1ml(100µg/ml)0.2µmfilteredantibodysolutioninPBS,containing0.1%bovineserumalbumin |
| Application | Flowcytometry,Functionalstudies,Immunoassays,Immunoprecipitation,Westernblot |
| Use | ForflowcytometryandWesternblotting,dilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50.Forfunctionalstudies,invitrodilutionshavetobeoptimizedinuser"sexperimentalsetting.AntibodyreactivitywithcellboundorsolubleTNF-RIisnotinhibitedbyhighconcentrationsofmouseTNFα. |
| Isotype | RabbitIg |
| Species | Mouse |
| Alias | Tumornecrosisfactorreceptorsuperfamilymember1A,TNF-RI,p55/p60 |
| References | 1.Lucas,Retal;BothTNFreceptorsarerequiredfordirectTNF-mediatedcytotoxicityinmicrovascularendothelialcells.EurJImmunol1998,28:3577 2.Bemelmans,Metal;LPS-InducedsTNF-receptorreleaseinvivoinamurinemodel.JImmunol1993,151:5554 3.Gerspach,Jetal;Detectionofmembrane-boundtumornecrosisfactor(TNF):ananalysisofTNF-specificreagents.MicrResTech2000,50:243 |
| StorageandstABIlity | Productshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear. |
| Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandfederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultfromtheuseorderivationofthisproduct. |
| Disease | Autoimmunity,Gastroenterology |
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。
联络我们
