Hycult Biotech/TLR7, Human, pAb/HP9040/100 µg
商品编号：
HP9040
品牌：
hycultbiotech
市场价：
¥9288.00
美元价：
5572.80
产品分类：
多克隆抗体
公司分类：
Polyclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Description:TLR7,Human,pAb
ThepolyclonalantibodyrecognizeshumanToll-likereceptor7.TLRsbelongtoafamilyofproteinsthatspecificallyrecognizesandsensesmicrobialproducts.Theyarehighlyconservedthroughoutevolutionandhavebeenimplicatedintheinnatedefensetomanypathogens.LikeitscounterpartsinDrosophilatollisrequiredfortheanti-fungalresponse,whiletherelated18-wheelerisinvolvedinantibacterialdefenses.Inmammals,TLRareidentifiedastypeItransmembranesignalingreceptorswithpatternrecognitioncapABIlities.ThevariousTLRsexhibitdifferentpatternsofexpression.TheTLR7geneispredominantlyexpressedinlung,placenta,andspleen,andislocatedincloseproximitytoanotherfamilymember,TLR8,onhumanchromosomeX.
TLR3,7,8and9belongtoathirdclassofTLRswhicharelocalizedintracellularwheretheydetectnucleicacidsderivedfromvirusesandbacteria.TLR7isrecognizedbysinglestrandedRNAinendosomes,whichisacommonfeatureofviralgenomeswhichareinternalizedbymacrophages.TLR7proteinsarelocalizedinendosomesand/orlysosomes.Recently,ithasbeendiscoveredthatTLR3,TLR7andTLR9traffickingrequiresUNC93B1,a12-membranespanningproteinthatresidesintheendoplasmaticreticulum.MiceorcellsthatlackUNC93B1function,aredefectiveinTLR3,TLR7andTLR9signaling.AssociationofUNC93B1withTLRsintheERfacilitatestheirtransporttotheendolysosome.
NKcellsareactivatedthroughTLR7/8andreportacentralroleformonocyte-derivedIL-12inthedifferentialIFN-producedbyNKcellsinresponsetodifferentTLRagoNISTs.
TLR3,7,8and9belongtoathirdclassofTLRswhicharelocalizedintracellularwheretheydetectnucleicacidsderivedfromvirusesandbacteria.TLR7isrecognizedbysinglestrandedRNAinendosomes,whichisacommonfeatureofviralgenomeswhichareinternalizedbymacrophages.TLR7proteinsarelocalizedinendosomesand/orlysosomes.Recently,ithasbeendiscoveredthatTLR3,TLR7andTLR9traffickingrequiresUNC93B1,a12-membranespanningproteinthatresidesintheendoplasmaticreticulum.MiceorcellsthatlackUNC93B1function,aredefectiveinTLR3,TLR7andTLR9signaling.AssociationofUNC93B1withTLRsintheERfacilitatestheirtransporttotheendolysosome.
NKcellsareactivatedthroughTLR7/8andreportacentralroleformonocyte-derivedIL-12inthedifferentialIFN-producedbyNKcellsinresponsetodifferentTLRagoNISTs.
Specifications:
| Catalognumber | HP9040 |
|---|---|
| Producttype | Polyclonalantibodies |
| Quantity | 100µg |
| Formulation | 1ml(100µg/ml)0.2µmfilteredantibodysolutioninPBS,containing0.1%bovineserumalbuminand0.02%sodiumazide. |
| Application | Flowcytometry,Frozensections,Immunofluorescence,Immunoprecipitation,Paraffinsections,Westernblot |
| Use | Forimmunohistology,flowcytometryandWesternblotting,dilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50. |
| Immunogen | SyntheticpeptideofhumanTLR7correspondingtoaminoacids706-728conjugatedtoKLH |
| Isotype | RabbitIg |
| Species | Human |
| Alias | Toll-likereceptor7 |
| References | 1.François,Setal;InhibitionofneutrophilapoptosisbyTLRagonistsinwholeblood:involvementofthephosphoinositide3-kinase/AktandNF-{kappa}Bsignalingpathways,leADIngtoincreasedlevelsofMcl-1,A1,andphosphorylatedbad.JImmunol2005,174:3633 2.Patole,Petal;ExpressionandregulationofToll-likereceptorsinlupus-likeimmunecomplexglomerulonephritisofMRL-Fas(lpr)mice.NephrolDialTransplant2006,21:3062 3.Pawar,Retal;Toll-likereceptor-7modulatesimmunecomplexglomerulonephritis.JAmSocNephrol2006,17:141 4.Brinkmann,Metal;TheinteractionbetweentheERmembraneproteinUNC93BandTLR3,7and9iscrucialforTLRsignaling.JCellBiol2007,177:265 5.Clark,Retal;HumansquamouscellcarcinomasevadetheimmuneresponsebydownregulationofvascularE-selectinandrecruitmentofregulatoryTcells.JExpMed2008,205:2221 |
| Storageandstability | Productshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear. |
| Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandfederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultfromtheuseorderivationofthisproduct. |
| Disease | Infectiousdiseases |
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。
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