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Hycult Biotech/TNF-RII, Human, mAb MR2-1, FITC/HM2007F/100 µg
Hycult Biotech/TNF-RII, Human, mAb MR2-1, FITC/HM2007F/100 µg
商品编号：
HM2007F
品牌：
hycultbiotech
市场价：
¥11616.00
美元价：
6969.60
产品分类：
单克隆抗体
公司分类：
monoclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Description:TNF-RII,Human,mAbMR2-1,FITC
TheantibodyMR2-1reactswiththeextra-cellularpartoftheTNF-RII.Italsoreactswiththesolublereceptor.TNF-RIIispresentonmostcelltypesandisconsideredtoplayaprominentroleincellstimulationbyTNF-alpha.TNF-RIImoleculeisshowntoberesponsIBLeforstimulationofactivatedT-lymphocytesbyTNF-alpha.TheantibodycrossreactswithrhesusandcynomolgusnaturalTNF-RII.
Specifications:
| Catalognumber | HM2007F |
|---|---|
| Producttype | Monoclonalantibodies |
| Quantity | 100µg |
| Formulation | 1ml(100μg/ml)0.2μmfilteredproteinGpurifiedFITCconjugatedantibodysolutioninPBS,containing1%bovineserumalbuminand0.02%sodiumazide. |
| Conjugate | FITC |
| Application | Flowcytometry,Functionalstudies,Immunoassays,Immunofluorescence,Immunoprecipitation,Westernblot |
| ApplicationNotes | IA:HM2007canbeusedasacaptureantibody. IP:Thelysatewascentrifugedandthesupernatantwasincubatedwith5mgTNFR2-specificantibodyMR2-1for2hoursat4°C.TheimmunocomplexeswereprecipitatedwithproteinGagarosefortwohoursat4°C(Ref.4). W:Areducedprotocolwasused.Theexpectedbandsizeis~65kDa. |
| Use | Dilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50. |
| Immunogen | sTNF-R75purifiedfromtheculturesupernatantofNSOcells(transfectedwiththeextracellularpartofTNF-R75)(Ref.1). |
| Isotype | MouseIgG1 |
| Species | Human |
| Crossreactivity | Cynomolgusmonkey-Yes,Rhesusmonkey-Yes |
| Alias | Tumornecrosisfactorreceptorsuperfamilymember1B,Tumornecrosisfactorreceptor2,TNF-R2,TumornecrosisfactorreceptortypeII,TNFR-II,p75,p80TNF-alphareceptor,CD120b Genename:TNFRSF1B,TNFBR,TNFR2 |
| References | 1.Leeuwenberg,JFMetal;LipopolysaccharideLPS-mediatedsolubleTNF-ReceptorreleaseandTNF-Receptorexpressionbymonocytes;roleofCD14,LPSbindingproteinandbactericidal/permeABIlity-increasingprotein.JImmnol1994,152:5070 2.Leeuwenberg,JFMetal;SlowreleaseofsolubleTNF-Receptorsbymonocytesinvitro.JImmunol1994,152:4036 3.Marchetti,Letal;Tumornecrosisfactor(TNF)-mediatedneuroprotectionagainstglutamate-inducedexcitotoxicityisenhancedbyN-methyl-D-aspartatereceptoractivation.EssentialroleofaTNFreceptor2-mediatedphosphatidylinositol3-kinase-dependentNF-kappaBpathway.JBiolChem2004,279:32869 4.Fisher,Retal,ATNFReceptor2SelectiveAgoNISTRescuesHumanNeuronsfromOxidativeStress-InducedCellDeath.PLoSONE2011,6:e27621 5.Richter,Cetal.TheTumorNecrosisFactorReceptorStalkRegionsDefineResponsivenesstoSolubleversusMembrane-BoundLigand.MolecularandCellularBIOLOGy2012,32:2515 6.Okubo,Yetal.HomogeneousExpansionofHumanT-RegulatoryCellsViaTumorNecrosisFactorReceptor2.NatureSCIENTIFICREPORTS2013,3:3153 7.He,Xetal;ATNFR2-AgonistFacilitatesHighPurityExpansionofHumanLowPurityTregCells.PLoSONE2016,11:e0156311 8.Nguyen,Detal;Anti-TNFdrivesregulatoryTcellexpansionbyparadoxicallypromotingmembraneTNF–TNF-RIIbindinginrheumatoidarthritis.J.Exp.Med.2016,213:1241 |
| Storageandstability | Productshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforatleastoneyear. |
| Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandfederalrulesintheuseofthisproduct.Hbtisnotresponsibleforanypatentinfringementsthatmightresultfromtheuseorderivationofthisproduct. |
| Disease | Autoimmunity,Gastroenterology |
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。
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