Hycult Biotech/乳铁蛋白，小鼠，单克隆抗体1A10/HM1132/100µg
商品编号：
HM1132
品牌：
hycultbiotech
市场价：
¥8736.00
美元价：
5241.60
产品分类：
单克隆抗体
公司分类：
monoclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Description:Lactoferrin,Mouse,mAb1A10
Monoclonalantibodyclone1A10recognizesmouselactoferrin(LF).Theexpressionofsmallproteinsandpeptideswithmicrobialactivity,alsocalledantimicrobialpeptides(AMPs),isconsideredtobeaprimitivemechanismofimmunity.AMPsareproducedbyalmostallcelltypeswhicharecommonlyexposedtomicrobes.LactoferrinisamultifunctionalAMPandamajorelementofinnateimmunitybutalsoaffectsadaptiveimmunefunctions.LFisawellconservedmammaliannon-haemiron-binding80kDmonomericglycoproteinofthetransferrinfamily.Theproteinisfoundinmucosalsecretionlikesaliva,tears,urine,vaginalfluids,semen,urineandveryhighconcentrationsin(colostral)milk(1-7mg/ml).Itsprotectiveeffectsrangefromdirectantimicrobialactivitiesagainstalargepanelofmicroorganisms,includingbacteria,viruses,fungiandparasites,toanti-inflammatoryandanticanceractivities.ThemainfunctionsofLFresidedinspecificdomainsandhavepredominantlybefoundintheN-terminalside.Oneofthemainfunctionsisinhibitionofmicrobialgrowthbysequestrationofiron,whichisessentialforgrowth.TheN-terminalstructureofLFismainlyresponsIBLeforthisfunction.TheN-terminaldomaincontainsalsoaserine-protease-likeactivitywhichisinvolvedininactivationofhostcellinvasionbybacteria.Followinginfection,LFisreleasedfromsecondary-granulesofneutrophilsinbloodandinflamedtissueandfunctionsaspattern-recognitionreceptor.Therefore,LFplasmaconcentrationrepresentsapositiverelationtothetotalpoolofneutrophilsandtherateofneutrophilturnoverandcanbeusedasanindexforneutrophilactivation.Intheadaptiveimmuneresponse,LFpromotesthematurationofT-cellprecursorsintocompetenthelpercellsandbydifferentiationofimmatureB-cellsintoantigenpresentingcells.
Specifications:
| Catalognumber | HM1132 |
|---|---|
| Producttype | Monoclonalantibodies |
| Quantity | 100µg |
| Formulation | 1ml(100µg/ml)0.2µmfilteredantibodysolutioninPBS,containing0.1%bovineserumalbuminand0.02%sodiumazide. |
| Application | Flowcytometry,Immunoassays |
| ApplicationNotes | FC:Antibody1A10stainsintracellular.Forintracellularstaining293cellswerepermeABIlizedandstainedwith2 µg/ml1A10. |
| Use | ForImmunoAssay-dilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50.Forfunctionalstudies,invitrodilutionshavetobeoptimizedinuser’sexperimentalsetting. |
| Immunogen | Mouselactoferrinpeptide |
| Isotype | MouseIgG2b |
| Species | Mouse |
| Storageandstability | Productshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforatleastoneyear.Theexactexpirydateisindicatedonthelabel. |
| Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandfederalrulesintheuseofthisproduct.HycultBiotechisnotresponsibleforanypatentinfringementsthatmightresultfromtheuseorderivationofthisproduct. |
| Disease | Autoimmunity,Infectiousdiseases |
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。
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